Mitigation Effects of Bentonite and Yeast Cell Wall Binders on AFB(1), DON, and OTA Induced Changes in Laying Hen Performance, Egg Quality, and Health
文献类型： 外文期刊
作者： Zhao, Ling 1 ; Feng, Yue 1 ; Wei, Jing-Tao 3 ; Zhu, Meng-Xiang 1 ; Zhang, Lei 1 ; Zhang, Jia-Cai 4 ; Karrow, Niel Alex 1 ;
作者机构： 1.Huazhong Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, Wuhan 430070, Peoples R China
2.Huazhong Agr Univ, Natl Ctr Int Res Anim Genet Breeding & Reprod NCI, Wuhan 430070, Peoples R China
3.Hubei Acad Agr Sci, Inst Anim Husb & Vet Sci, Wuhan 430064, Peoples R China
4.Guangdong Haid Grp Co Ltd, Anim Husb & Fisheries Res Ctr, Guangzhou 511400, Peoples R China
5.Univ Guelph, Dept Anim Biosci, Guelph, ON N1G 2W1, Canada
6.Trouw Nutr, NL-773811 Amersfoort, Netherlands
7.China Agr Univ, Coll Anim Sci & Technol, State Key Lab Anim Nutr, Beijing 100193, Peoples R China
关键词： mycotoxins; laying hens; performance; binder; remediation
期刊名称：TOXINS （ 影响因子：4.546； 五年影响因子：4.8 ）
ISSN：
年卷期： 2021 年 13 卷 2 期
页码：
收录情况： SCI
摘要： The objective of this study was to evaluate the efficacy of mycotoxin binders in reducing the adverse effects of co-occurring dietary aflatoxin B-1 (AFB(1)), deoxynivalenol (DON) and ochratoxin A (OTA) on laying hens. Three hundred and sixty 26-week-old Roman laying hens were randomly allocated into four experimental groups with 10 replicates of nine birds each. The four groups received either a basal diet (BD; Control), a BD supplemented with 0.15 mg/kg AFB(1) + 1.5 mg/kg DON + 0.12 mg/kg OTA (Toxins), a BD + Toxins with Toxo-HP binder (Toxins + HP), or a BD + Toxins with TOXO XL binder (Toxins + XL) for 12 weeks. Compared to the control, dietary supplementation of mycotoxins decreased (P < 0.10) total feed intake, total egg weight, and egg-laying rate, but increased feed/egg ratio by 2.5-6.1% and mortality during various experimental periods. These alterations induced by mycotoxins were alleviated by supplementation with both TOXO HP and XL binders (P < 0.10). Furthermore, dietary mycotoxins reduced (P < 0.05) eggshell strength by 12.3% and caused an accumulation of 249 mu g/kg of DON in eggs at week 12, while dietary supplementation with TOXO HP or XL mitigated DON-induced changes on eggshell strength and prevented accumulation of DON in eggs (P < 0.05). Moreover, dietary mycotoxins increased relative liver weight, but decreased spleen and proventriculus relative weights by 11.6-22.4% (P < 0.05). Mycotoxin exposure also increased alanine aminotransferase activity and reduced immunoglobulin (Ig) A, IgM, and IgG concentrations in serum by 9.2-26.1% (P < 0.05). Additionally, mycotoxin exposure induced histopathological damage and reduced villus height, villus height/crypt depth, and crypt depth in duodenum, jejunum and (or) ileum (P < 0.05). Notably, most of these histological changes were mitigated by supplementation with both TOXO HP and XL (P < 0.05). In conclusion, the present study demonstrated that the mycotoxin binders TOXO HP and XL can help to mitigate the combined effects of AFB(1), DON, and OTA on laying hen performance, egg quality, and health.
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