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Characterization of porcine circovirus-like virus P1 replication and lesions in BALB/c mice

文献类型： 外文期刊

作者： Wen, Libin 1 ; Gao, Xiaojing 1 ; Sheng, Shaoyang 1 ; Xiao, Qi 1 ; Wang, Wei 1 ; He, Kongwang 1 ;

作者机构： 1.Jilin Acad Agr Sci, Changchun, Peoples R China

关键词： Porcine circovirus-like virus P1; BALB; C mice; Replication

期刊名称：VIROLOGY （ 影响因子：3.616； 五年影响因子：3.967 ）

ISSN： 0042-6822

年卷期： 2021 年 556 卷

页码：

收录情况： SCI

摘要： Five-week-old male BALB/c mice were inoculated intraperitoneally with a single (sP1) or multiple doses (mP1) of porcine circovirus-like virus P1 or cell culture medium. None of the mice exhibited clinical signs or gross lesions throughout the study. However, the body weights of the mP1 mice were significantly decreased, and the mice inoculated with P1 exhibited viral replication, seroconversion, and microscopic lesions. P1 nucleic acid was detected in the heart, liver, spleen, lung, bladder, testis, brain, thymus, and pancreatic tissues. Special P1 antibody was found in the P1-inoculated mice. Microscopic lesions in the sP1 and mP1 mice were characterized by interstitial pneumonia, including edema in the connective tissue around the pulmonary vessels, mild inflammatory cell infiltrate, thickened alveolar walls, myocardial necrosis, and dissolution of Purkinje cell nuclei. The results showed that the P1 virus could infect BALB/c mice. Thus, BALB/c mice may serve as models for P1 research.

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