文献类型： 外文期刊
作者： Zhang, Yuqian 1 ; Zhang, Guofang 1 ; Wang, Guocheng 2 ; Wu, Lidong 3 ; Monteiro-Riviere, Nancy A. 4 ; Li, Yang 1 ;
作者机构： 1.Chinese Acad Sci, Shenzhen Inst Adv Technol, Lab Immunol & Nanomed, Shenzhen 518055, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Shenzhen, Peoples R China
3.Chinese Acad Fishery Sci, Key Lab Control Qual & Safety Aquat Prod, Beijing, Peoples R China
4.Kansas State Univ, Nanotechnol Innovat Ctr Kansas State, Manhattan, KS 66506 USA
关键词： immune checkpoints; immuno‐ oncotherapy; nanomaterials; nanoagents; photothermal therapy; synergistic oncotherapy
期刊名称：WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY （ 影响因子：7.689； 五年影响因子：7.017 ）
ISSN： 1939-5116
年卷期：
页码：
收录情况： SCI
摘要： Immuno-oncotherapy has shown great promise for the cure of late-stage and metastatic cancer. Great efforts have tried to improve the overall response rate (ORR) and to reduce the immune-related adverse events (irAEs). Antigen presentation, T cell activation and killing are interlocking and distinct steps to initiate effective anti-tumor immune responses. Aiming to overcome the tumor immune evasion whose mechanisms include limited release of neoantigen, suppressed infiltration of antigen-presenting cells (APCs) and T cells, and the expression of immune checkpoints (ICPs), combinational therapeutic strategies have shown great potential by activating the anti-tumor immune responses together with deactivating immunosuppressive conditions simultaneously. In this direction, photothermal therapy (PTT) has attracted attention due to the efficient ablation of tumor cells, of which the released immunogenic tumor debris can activate host immune responses. The combination of immunoadjuvants and/or ICP inhibitors can boost the anti-tumor immune responses, realizing PTT-synergized immuno-oncotherapy. In this regard, numerous multifunctional nanomaterials have been designed with integration of photothermal and immuno-oncotherapeutic agents into one package via well-designed surface modification and functionalization. This review summarizes the recent studies on the synergistic strategies for the immuno-oncotherapy based on photothermal nanoagents and the mechanisms that trigger the systemic anti-tumor immune responses and PTT-synergized immuno-oncotherapy. This article is categorized under: Therapeutic Approaches and Drug Discovery > Nanomedicine for Oncologic Disease
- 相关文献
作者其他论文 更多>>
-
The Mitogenomic Landscape of Hexacorallia Corals: Insight into Their Slow Evolution
作者：Wei, Zhanfei;Shao, Changwei;Wei, Zhanfei;Yang, Yang;Zhang, Nannan;Liu, Shanshan;Meng, Liang;Yang, Yang;Meng, Lihui;Li, Yang
关键词：deep-sea corals; Hexacorallia; mitogenomes; phylogenetics
-
Environmental Influences on Illex argentinus Trawling Grounds in the Southwest Atlantic High Seas
作者：Xiang, Delong;Li, Yang;Jiang, Keji;Han, Haibin;Wang, Yuhan;Yang, Shenglong;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Li, Yang;Jiang, Keji;Han, Haibin;Wang, Yuhan;Yang, Shenglong;Zhang, Heng;Sun, Yuyan;Xiang, Delong;Jiang, Keji;Han, Haibin;Sun, Yuyan;Li, Yang;Wang, Yuhan
关键词：fishing ground of squid; marine environment; spatiotemporal variation; the Maxent model
-
Marine aquaculture can deliver 40% lower carbon footprints than freshwater aquaculture based on feed, energy and biogeochemical cycles
作者：Shen, Lu;Lin, Jintai;Shen, Lu;Wu, Lidong;Wu, Lidong;Wei, Wei;Yang, Yi;MacLeod, Michael J.;Song, Guodong;Song, Guodong;Yuan, Junji;Yang, Ping;Wu, Lin;Li, Mingwei;Zhuang, Minghao
关键词：
-
Soft, Stretchable, and Conductive Hydrogel Based on Liquid Metal for Accurately Facial Expression Monitoring
作者：Qin, Haiyang;Sun, Mengmeng;Li, Peiyi;Wu, Lidong;Qin, Haiyang;Sun, Mengmeng;Li, Peiyi;Wu, Lidong;Li, Junye;Pan, Xiaofang;Zhang, Zhilin;Lu, Baoyang;Dai, Shuqi;Huang, Mingjun
关键词：hyaluronic acid; hydrogels; liquid metals; self-organizing neural networks; wearable sensor arrays
-
Scalable biomimetic sensing system with membrane receptor dual-monolayer probe and graphene transistor arrays
作者：Qing, Rui;Qing, Rui;Zhang, Shuguang;Qing, Rui;Xue, Mantian;Palacios, Tomas;Zhao, Jiayuan;Azzellino, Giovanni;Kong, Jing;Wu, Lidong;Breitwieser, Andreas;Sleytr, Uwe B.;Smorodina, Eva;Smorodina, Eva;Schubert, Thomas;Jin, David
关键词：
-
Response of the Northwest Indian Ocean purpleback flying squid (Sthenoteuthis oualaniensis) fishing grounds to marine environmental changes and its prediction model construction based on multi-models and multi-spatial and temporal scales
作者：Han, Haibin;Jiang, Bohui;Shi, Yongchuang;Zhang, Heng;Shang, Chen;Sun, Yuyan;Li, Yang;Xiang, Delong;Han, Haibin;Jiang, Bohui;Shi, Yongchuang;Zhang, Heng;Shang, Chen;Sun, Yuyan;Li, Yang;Xiang, Delong;Han, Haibin;Jiang, Bohui;Shang, Chen;Sun, Yuyan;Xiang, Delong;Jiang, Peiwen;Li, Yang
关键词：Northwest Indian Ocean; Sthenoteuthis oualaniensis; Temporal and spatial scales; Environment variables; Models
-
Polydopamine-triggered adhesive and conductive hydrogel for Morse code communication at polar environments
作者：Sun, Mengmeng;Qin, Haiyang;Li, Peiyi;Li, Yuanxin;Zhao, Jinxue;Zhai, Xuejing;Wu, Lidong;Sun, Mengmeng;Qin, Haiyang;Li, Peiyi;Zhao, Jinxue;Wu, Lidong;Xiang, Xueping;Li, Yuanxin;Zhai, Xuejing
关键词：Anti-freezing; Conductive hydrogel; Adhesive at low temperature; Morse code communication
