Comparative Study on the Protective Effect of Chlorogenic Acid and 3-(3-Hydroxyphenyl) Propionic Acid against Cadmium-Induced Erythrocyte Cytotoxicity: In Vitro and In Vivo Evaluation
文献类型： 外文期刊
作者： Cheng, Dai 1 ; Song, Qi 1 ; Ding, Yixin 1 ; Yu, Qianqian 1 ; Liu, Yutong 1 ; Tian, Xuena 1 ; Wang, Meng 2 ; Wang, Guangli 1 ;
作者机构： 1.Tianjin Univ Sci & Technol, State Key Lab Food Nutr & Safety, Tianjin 300457, Peoples R China
2.Beijing Res Ctr Agr Stand & Testing, Beijing 100097, Peoples R China
3.Nankai Univ, Sch Med, Tianjin Key Lab Food Sci & Hlth, Tianjin 300071, Peoples R China
关键词： erythrocyte; cadmium; chlorogenic acid; 3-(3-hydroxyphenyl) propionic acid; comparative study
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：4.192； 五年影响因子：4.289 ）
ISSN： 0021-8561
年卷期： 2021 年 69 卷 13 期
页码：
收录情况： SCI
摘要： The metabolism of chlorogenic acid (CGA) through the intestinal tract was studied. As cadmium is a well-known toxic heavy metal, this study was carried out to investigate the comparative protective effect of CGA and its representative intestinal metabolite (3-(3-hydroxyphenyl) propionic acid, HPPA) against Cd-induced erythrocyte cytotoxicity in vitro and in vivo. We found that CGA and its intestinal metabolite appreciably prevented erythrocyte hemolysis, osmotic fragility, and oxidative stress induced by Cd. Also, we found that HPPA had a stronger protective ability than CGA against Cd-induced erythrocyte injury in vivo, such as increasing the ratio of protein kinase C from 7.7% (CGA) to 12.0% (HPPA). Therefore, we hypothesized that CGA and its microbial metabolite had protective effects against Cd-induced erythrocyte damage via multiple actions including antioxidation and chelation. For humans, CGA supplementation may be favorable for avoiding Cd-induced biotoxicity.
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