文献类型： 外文期刊

作者： Han, Qinghua ¹ ; Qian, Yi ¹ ; Wang, Xuda ¹ ; Zhang, Qingying ¹ ; Cui, Jingrong ¹ ; Tu, Pengfei ¹ ; Liang, Hong ¹ ;

作者机构： 1.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

2.Peking Univ, Sch Pharmaceut Sci, Hlth Sci Ctr, Dept Nat Med, Beijing 100191, Peoples R China

3.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Shanghai 200090, Peoples R China

关键词： Albizia julibrissin Durazz.; Leguminosae; Oleanane-type saponins; Oleanane-type prosapogenins; Cytotoxic activities

期刊名称：PHYTOCHEMISTRY （ 影响因子：3.044； 五年影响因子：3.374 ）

ISSN： 0031-9422

年卷期： 2021 年 185 卷

页码：

收录情况： SCI

摘要： Two undescribed oleanane-type saponins, julibrosides K-L, along with three undescribed oleanane-type prosapogenins, julibrosides M-O, were isolated from the stem bark of Albizia julibrissin Durazz. and the mild alkaline hydrolysate of the total saponin, respectively. Their structures were established by extensive analysis of 1D and 2D NMR experiments (COSY, TOCSY, HSQC, HMBC, and HSQC-TOCSY) and mass spectrometry. Furthermore, the cytotoxic activities of the isolated compounds against BGC-823, A549, HCT-116, and HepG2 cell lines were evaluated, and julibroside L showed significant cytotoxic activities against the four cancer cell lines with IC50 values of 5.77, 4.80, 4.26, and 4.93 mu M, respectively.