A Multifunctional N-Doped Cu-MOFs (N-Cu-MOF) Nanomaterial-Driven Electrochemical Aptasensor for Sensitive Detection of Deoxynivalenol
文献类型： 外文期刊
作者： Wen, Xiaoyan 1 ; Huang, Qingwen 2 ; Nie, Dongxia 1 ; Zhao, Xiuying 1 ; Cao, Haojie 1 ; Wu, Wenhui 1 ; Han, Zheng 1 ;
作者机构： 1.Shanghai Ocean Univ, Coll Food Sci & Technol, Shanghai 201306, Peoples R China
2.Shanghai Acad Agr Sci, Shanghai Key Lab Protected Hort Technol, Inst Agrofood Stand & Testing Technol,Minist Agr, Lab Qual & Safety Risk Assessment Agroprod Shangh, Shanghai 201403, Peoples R China
关键词： N-doped Cu– MOFs (N– Cu– MOF); deoxynivalenol; electrochemical aptasensor; wheat
期刊名称：MOLECULES （ 影响因子：3.267； 五年影响因子：3.589 ）
ISSN：
年卷期： 2021 年 26 卷 8 期
页码：
收录情况： SCI
摘要： Deoxynivalenol (DON) is one of the most common mycotoxins in grains, causing gastrointestinal inflammation, neurotoxicity, hepatotoxicity and embryotoxicity, even at a low quantity. In this study, a facile electrochemical aptasensor was established for the rapid and sensitive determination of DON based on a multifunctional N-doped Cu-metallic organic framework (N-Cu-MOF) nanomaterial. The N-Cu-MOF, with a large specific surface area and good electrical conductivity, served not only as an optimal electrical signal probe but also as an effective supporting substrate for stabilizing aptamers through the interactions of amino (-NH2) and copper. Under the optimal conditions, the proposed sensor provided a wide linear concentration range of 0.02-20 ng mL(-1) (R-2 = 0.994), showing high sensitivity, with a lower detection limit of 0.008 ng mL(-1), and good selectivity. The sensor's effectiveness was also verified in real spiked wheat samples with satisfactory recoveries of 95.6-105.9%. The current work provides a flexible approach for the rapid and sensitive analysis of highly toxic DON in food samples and may also be easily extended to detect other hazardous substances with alternative target-recognition aptamers.
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