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The hypoglycemic effect of freeze-dried fermented mulberry mixed with soybean on type 2 diabetes mellitus

文献类型： 外文期刊

作者： Long, Xiao-Shan 1 ; Liao, Sen-Tai 1 ; Li, Er-Na 1 ; Pang, Dao-Rui 1 ; Li, Qian 1 ; Liu, Shu-Cheng 2 ; Hu, Teng-Gen 1 ; Zo 1 ;

作者机构： 1.Guangdong Acad Agr Sci, Minist Agr & Rural Affairs, Guangdong Key Lab Agr Prod Proc, Key Lab Funct Foods,Sericultural & Agrifood Res I, 133 Yiheng St,Dongguanzhuang Rd, Guangzhou 510610, Peoples R China

2.Guangdong Ocean Univ, Guangdong Prov Key Lab Aquat Prod Proc & Safety, Key Lab Adv Proc Aquat Prod, Coll Food Sci & Technol,Guangdong Higher Educ Ins, Zhanjiang, Peoples R China

3.South China Univ Technol, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Sch Food Sci & Engn, Guangzhou, Peoples R China

关键词： fermented mulberry; gut microbiota; hypoglycemic effect; probiotics; soybean; type 2 diabetes mellitus

期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：1.797； ）

ISSN： 2048-7177

年卷期：

页码：

收录情况： SCI

摘要： Mulberry has significant hypoglycemic effect and can be used as an auxiliary food for people with type 2 diabetes. However, it is rich in carbohydrate and cannot be consumed directly by diabetic patients. In the study, we fermented the mulberry to reduce the content of glucose and fructose, and added the soybean to reduce the loss of probiotics during fermentation and then determined its hypoglycemic effect. We induced type 2 diabetes mellitus (T2DM) mice by streptozotocin and measured its blood glucose, serum biochemistry, hepatic and pancreatic histopathology, and the diversity of the gut microbiota. After 5 weeks of oral DFMS administration, the glucose tolerance was improved significantly in T2DM mice. Furthermore, there were also significant increases in superoxide dismutase activity and glutathione concentration, and marked reductions in the concentrations of malondialdehyde and free fatty acids. Moreover, DFMS also prevented histopathological changes and the increases in the activities of alanine transaminase and aspartate transaminase. DFMS treatment also markedly increased the richness of the gut microbial community. The abundance of Bacteroidetes was increased, and those of Proteobacteria, Escherichia-Shigella, and Lactobacillus were reduced. In summary, DFMS has a clear hypoglycemic effect in mice with T2DM.

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