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Generation and evaluation of IgY-scFv based mimetics against canine parvovirus

文献类型： 外文期刊

作者： Ge, Shikun 1 ; Zhang, Xingxing 4 ; Zhong, Fagang 4 ; Liu, Xiang 1 ; Zhang, Xiaoying 1 ;

作者机构： 1.Shaanxi Univ Technol, Sch Biol Sci & Engn, Key Lab Biol Resources & Ecol Environm Qinba Area, Chinese German Joint Lab Nat Prod Res, Hanzhong, Peoples R China

2.Univ Minho, Ctr Mol & Environm Biol, Campus Gualtar, P-4710057 Braga, Portugal

3.Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON, Canada

4.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China

关键词： Antibody mimetics; IgY-peptide; Canine parvovirus (CPV); IgY-scFv; IgY technology

期刊名称：VETERINARY RESEARCH （ 影响因子：3.357； 五年影响因子：3.432 ）

ISSN： 0928-4249

年卷期： 2021 年 52 卷 1 期

页码：

收录情况： SCI

摘要： Antibody mimetics may be used for various biomedical applications, especially those for which conventional antibodies are ineffective. In this study, we developed a smaller molecular chicken IgY mimetic peptide (IgY-peptide) based on the complementarity-determining regions (CDRs) of the anti-canine parvovirus (CPV) IgY-scFv prepared previously. The mimetic peptide showed no cross-reactivity with canine distemper virus (CDV) and canine coronavirus (CCV) and showed excellent protective properties for Crandell-Rees Feline Kidney (CRFK) cells against CPV. This study is the first attempt to develop a mimetic IgY-peptide and demonstrates the ease and feasibility in generating such a novel antibody-like functional molecule for biomedical purposes.

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