文献类型： 外文期刊
作者： Ge, Shikun 1 ; Zhang, Xingxing 4 ; Zhong, Fagang 4 ; Liu, Xiang 1 ; Zhang, Xiaoying 1 ;
作者机构： 1.Shaanxi Univ Technol, Sch Biol Sci & Engn, Key Lab Biol Resources & Ecol Environm Qinba Area, Chinese German Joint Lab Nat Prod Res, Hanzhong, Peoples R China
2.Univ Minho, Ctr Mol & Environm Biol, Campus Gualtar, P-4710057 Braga, Portugal
3.Univ Guelph, Ontario Vet Coll, Dept Biomed Sci, Guelph, ON, Canada
4.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Prod, Shihezi, Peoples R China
关键词： Antibody mimetics; IgY-peptide; Canine parvovirus (CPV); IgY-scFv; IgY technology
期刊名称：VETERINARY RESEARCH （ 影响因子：3.357； 五年影响因子：3.432 ）
ISSN： 0928-4249
年卷期： 2021 年 52 卷 1 期
页码：
收录情况： SCI
摘要： Antibody mimetics may be used for various biomedical applications, especially those for which conventional antibodies are ineffective. In this study, we developed a smaller molecular chicken IgY mimetic peptide (IgY-peptide) based on the complementarity-determining regions (CDRs) of the anti-canine parvovirus (CPV) IgY-scFv prepared previously. The mimetic peptide showed no cross-reactivity with canine distemper virus (CDV) and canine coronavirus (CCV) and showed excellent protective properties for Crandell-Rees Feline Kidney (CRFK) cells against CPV. This study is the first attempt to develop a mimetic IgY-peptide and demonstrates the ease and feasibility in generating such a novel antibody-like functional molecule for biomedical purposes.
- 相关文献
作者其他论文 更多>>
-
Drivers of the emergence and dissemination of high-risk resistance genes in cattle farm
作者：Jiao, Yanxiang;Zhang, Xingxing;Yang, Feifan;Lv, Luchao;Gao, Yingbo;Cai, Zhongpeng;Pu, Wenxian;Gao, Guolong;Liu, Jian-Hua;Jiao, Yanxiang;Zhang, Xingxing;Yang, Feifan;Lv, Luchao;Gao, Yingbo;Cai, Zhongpeng;Pu, Wenxian;Gao, Guolong;Liu, Jian-Hua;Zhang, Xingxing;Zhong, Fagang;He, Dandan
关键词：Antimicrobial resistance; Extended-spectrum beta-lactamase; Carbapenemase; Transmission risk factors; One Health strategy
-
Epidemiological and molecular characteristics of extraintestinal pathogenic escherichia coli isolated from diseased cattle and sheep in Xinjiang, China from 2015 to 2019
作者：Gu, Xiaoxiao;Wu, Qin;Chai, Yingjin;Zhou, Xia;Huang, Xin;Han, Mengli;Wu, Tongzhong;Zhang, Xingxing;Zhong, Fagang
关键词：ExPEC; Phylogenetic grouping; Serotype; Multilocus sequence typing; Biofilm
-
Protective Efficacy of Subunit Vaccine Expressing Rv0976c Against Tuberculosis
作者：Zhou, Ziwei;Chen, Fuzeng;Xiang, Zhihao;Gao, Xiaoxiao;Li, Yeyu;Chen, Dan;Zhang, Lu;Xu, Wenxi;Pan, Zhifen;Zhong, Fagang;Liu, Jun;Zhang, Lu
关键词：tuberculosis; antigens; subunit vaccines; Rv0976c; protective efficacy
-
Estimation of Genetic Parameters for Body Weight and Its Stability in Huaxi Cows from Xinjiang Region
作者：Feng, Ye;Lu, Xubin;Chen, Zhi;Zhao, Wenjuan;Zhang, Qian;Zhang, Bin;Wang, Bao;Zhong, Fagang;Han, Mengli;Gao, Xue
关键词：adult weight; birth weight; heritability; genetic analysis; West China cattle
-
Adenylate Cyclase Affects the Virulence of Extraintestinal Pathogenic Escherichia coli Derived from Sheep Lungs
作者：Chai, Yingjin;Huang, Xin;Han, Mengli;Zhong, Fagang;Zhang, Xingxing;Wu, Tongzhong;Chai, Yingjin;Gu, Xiaoxiao;Li, Jie;Wang, Xiaolan;Zhou, Xia;Sun, Yingni
关键词：Adhesion and invasion; cyaA; Median lethal dose; XJ10
-
Isolation, Identification and Antibacterial Resistance Spectrum of Bacterial Pathogens of Respiratory Tract Infection in a Large-Scale Cattle Farm
作者：Guo, Yunxia;Zhou, Xia;Huang, Xin;Zhong, Fagang
关键词：Respiratory tract infections; Antimicrobial; Susceptibility; Bovine; Pneumonia
-
STnc1280, a trans- coding sRNA is involved in virulence modulation via targeting gldA mRNA in Salmonella Typhimurium
作者：Ning, Chengcheng;Li, Na;Wang, Lixia;Guo, Yun;Ji, Chunhui;Li, Zhiyuan;Shang, Yunxia;Sun, Yaoqiang;Huang, Xiaoxing;Leng, Qingwen;Meng, Qingling;Qiao, Jun;Ning, Chengcheng;Zhang, Xingxing;Cai, Xuepeng
关键词：modulation; Salmonella Typhimurium; sRNA; STnc1280; virulence
