文献类型： 外文期刊
作者： Xia, Yaoyao 1 ; Li, Yikun 2 ; Wu, Xiaoyan 2 ; Zhang, Qingzhuo 2 ; Chen, Siyuan 2 ; Ma, Xianyong 1 ; Yu, Miao 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Guangdong Engn Technol Res Ctr Anim Meat Qual & S, Minist Agr & Rural Affairs,Key Lab Anim Nutr & Fe, Inst Anim Sci,State Key Lab Livestock & Poultry B, Guangzhou, Peoples R China
2.South China Agr Univ, Coll Anim Sci, Guangzhou, Peoples R China
3.Guangdong Lab Lingnan Modern Agr, Maoming Branch, Guangzhou, Peoples R China
关键词： iron; inflammation; macrophage; metabolism; epigenetics
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：5.085； 五年影响因子：5.733 ）
ISSN： 1664-3224
年卷期： 2021 年 12 卷
页码：
收录情况： SCI
摘要： Iron fine-tunes innate immune responses, including macrophage inflammation. In this review, we summarize the current understanding about the iron in dictating macrophage polarization. Mechanistically, iron orchestrates macrophage polarization through several aspects, including cellular signaling, cellular metabolism, and epigenetic regulation. Therefore, iron modulates the development and progression of multiple macrophage-associated diseases, such as cancer, atherosclerosis, and liver diseases. Collectively, this review highlights the crucial role of iron for macrophage polarization, and indicates the potential application of iron supplementation as an adjuvant therapy in different inflammatory disorders relative to the balance of macrophage polarization.
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