文献类型： 外文期刊
作者： Zhang, Xinyu 1 ; Zhu, Chenyu 1 ; Zhang, Luyun 1 ; Tan, Luyi 1 ; Cheng, Wenli 1 ; Li, Min 1 ; Zhang, Xingtan 3 ; Zhang, Wenjuan 1 ; Zhang, Wenji 2 ;
作者机构： 1.Jinan Univ, Sch Med, Dept Publ Hlth & Prevent Med, Guangzhou 510640, Guangdong, Peoples R China
2.Guangdong Acad Agr Sci, Crops Res Inst, Key Lab Crop Genet Improvement Guangdong Prov, Guangzhou 510640, Guangdong, Peoples R China
3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Natl Key Lab Trop Crop Breeding, Shenzhen Branch,Guangdong Lab Lingnan Modern Agr,G, Shenzhen, Guangdong, Peoples R China
关键词： human embryonic lung fibroblasts; hydrogen peroxide; premature senescence; resveratrol; RNA m6A methylation
期刊名称：FOOD SCIENCE & NUTRITION （ 影响因子：3.8； 五年影响因子：4.5 ）
ISSN： 2048-7177
年卷期： 2024 年 12 卷 11 期
页码：
收录情况： SCI
摘要： Resveratrol, a natural compound found in various plants, is known for its anti-inflammatory, antioxidant, and senescence-delaying properties. RNA N6-methyladenosine (m6A) methylation plays a crucial role in oxidative stress and premature cellular senescence processes and is closely associated with age-related disorders. However, the anti-premature senescence via RNA m6A methylation mechanism of resveratrol is still not fully understood. In this study, based on premature senescence model of human embryonic lung fibroblasts (HEFs) induced by hydrogen peroxide (H2O2), a widely accepted model of premature senescence caused by oxidative stress, we explored the anti-aging regulatory effects of resveratrol at the RNA m6A methylation level. Our data suggested that resveratrol significantly delayed premature senescence by increasing cell viability, reducing SA-beta-gal blue staining rate, ROS levels, and senescence-associated secretory phenotypes (SASP) expression in HEFs. Meanwhile, resveratrol increased the whole RNA methyltransferases activity and the overall m6A level during senescence. Furthermore, three genes CCND2, E2F1, and GADD45B have been identified as the main ones regulating premature by resveratrol. Specifically, it decreased E2F1, GADD45B RNA m6A methylation level, and increased CCND2 level in premature cells. Our study provided new clues for exploring the mechanism and application of resveratrol in the field of premature aging.
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