Structural characterization of a polysaccharide from bamboo (Phyllostachys edulis) shoot and its prevention effect on colitis mouse
文献类型： 外文期刊
作者： Li, Qi 1 ; Wu, Weijie 1 ; Fang, Xiangjun 1 ; Chen, Hangjun 1 ; Han, Yanchao 1 ; Liu, Ruiling 1 ; Niu, Ben 1 ; Gao, Haiyan 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou 310021, Peoples R China
2.Minist Agr & Rural Affairs, Key Lab Postharvest Handling Fruits, Hangzhou 310021, Peoples R China
3.Key Lab Fruits & Vegetables Postharvest & Proc Te, Hangzhou 310021, Peoples R China
4.China Natl Light Ind, Key Lab Postharvest Preservat & Proc Fruits & Veg, Hangzhou 310021, Peoples R China
关键词： Anti-inflammatory activity; Bamboo shoots dietary fiber; Dextran sulfate sodium-induced colitis; Intestinal microbiota; Structural characteristics
期刊名称：FOOD CHEMISTRY （ 影响因子：9.231； 五年影响因子：8.795 ）
ISSN： 0308-8146
年卷期： 2022 年 387 卷
页码：
收录情况： SCI
摘要： A water-soluble dietary fiber named BSDF-1 (polysaccharide) was isolated from the bamboo (Phyllostachys edulis) shoot. BSDF-1was characterized as a backbone consisting predominately of 1,4-linked Glcp, and the protective effects and mechanisms of the anti-inflammatory activity were investigated using a dextran sulfate sodium (DSS)induced colitis mouse model. BSDF-1 administration significantly reduced colonic pathological damage, inhibited the activation of inflammatory signaling pathways, including nuclear factor-kappa B and NLR family pyrin domain containing 3 inflammasomes pathways. It restored the mRNA expression of tight junction proteins, including zonula occludens-1, claudin-1, and occludin. Furthermore, BSDF-1 treatment reduced Parabacteroides, Mucispirillum, Helicobacter, Bacteroides, and Streptococcus levels, whereas high-dose BSDF-1 treatment increased Prevotella, Alitipes, Anaerostipes, Odoribacter, Bifidobacterium, Butyricimonas, and Lactobacillus levels. In conclusion, BSDF-1 can inhibit the activation of inflammatory signaling pathways and restore the intestinal barrier function. Thus, BSDF-1 may be a valuable food supplement or nutraceutical to manage and prevent ulcerative colitis.
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