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Recent development and fighting strategies for lincosamide antibiotic resistance

文献类型： 外文期刊

作者： Yang, Yingying 1 ; Xie, Shiyu 3 ; He, Fangjing 3 ; Xu, Yindi 4 ; Wang, Zhifang 4 ; Ihsan, Awais 5 ; Wang, Xu 1 ;

作者机构： 1.Huazhong Agr Univ, Natl Reference Lab Vet Drug Residues HZAU, Wuhan, Hubei, Peoples R China

2.Huazhong Agr Univ, MAO Key Lab Detect Vet Drug Residues, Wuhan, Peoples R China

3.Huazhong Agr Univ, MOA Lab Risk Assessment Qual & Safety Livestock &, Wuhan, Hubei, Peoples R China

4.Henan Acad Agr Sci, Inst Anim Husb Res, Zhengzhou, Henan, Peoples R China

5.COMSATS Univ Islamabad, Dept Biosci, Sahiwal Campus, Islamadad, Pakistan

关键词： lincosamide; resistance; horizontal transfer; mobile genetic element; fighting strategies

期刊名称：CLINICAL MICROBIOLOGY REVIEWS （ 影响因子：36.8； 五年影响因子：37.4 ）

ISSN： 0893-8512

年卷期： 2024 年

页码：

收录情况： SCI

摘要： Lincosamides constitute an important class of antibiotics used against a wide range of pathogens, including methicillin-resistant Staphylococcus aureus. However, due to the misuse of lincosamide and co-selection pressure, the resistance to lincosamide has become a serious concern. It is urgently needed to carefully understand the phenomenon and mechanism of lincosamide resistance to effectively prevent and control lincosamide resistance. To date, six mobile lincosamide resistance classes, including lnu, cfr, erm, vga, lsa, and sal, have been identified. These lincosamide resistance genes are frequently found on mobile genetic elements (MGEs), such as plasmids, transposons, integrative and conjugative elements, genomic islands, and prophages. Additionally, MGEs harbor the genes that confer resistance not only to antimicrobial agents of other classes but also to metals and biocides. The ultimate purpose of discovering and summarizing bacterial resistance is to prevent, control, and combat resistance effectively. This review highlights four promising strategies, including chemical modification of antibiotics, the development of antimicrobial peptides, the initiation of bacterial self-destruct program, and antimicrobial stewardship, to fight against resistance and safeguard global health.

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