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Application of High-Throughput Sequencing on the Chinese Herbal Medicine for the Data-Mining of the Bioactive Compounds

文献类型： 外文期刊

作者： Liu, Xiaoyan 1 ; Gong, Xun 2 ; Liu, Yi 1 ; Liu, Junlin 1 ; Zhang, Hantao 1 ; Qiao, Sen 1 ; Li, Gang 4 ; Tang, Min 1 ;

作者机构： 1.Jiangsu Univ, Sch Life Sci, Zhenjiang, Peoples R China

2.Jiangsu Univ, Affiliated Hosp, Dept Rheumatol & Immunol, Zhenjiang, Peoples R China

3.Jiangsu Acad Agr Sci, Inst Anim Husb, Nanjing, Peoples R China

4.Shandong First Med Univ, Dept Vasc Surg, Affiliated Hosp 2, Tai An, Shandong, Peoples R China

关键词： Chinese herbal medicine; high-throughput sequencing technologies; genome assembly; bioactive compounds; functional genes

期刊名称：FRONTIERS IN PLANT SCIENCE （ 影响因子：6.627； 五年影响因子：7.255 ）

ISSN： 1664-462X

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： The Chinese Herbal Medicine (CHM) has been used worldwide in clinic to treat the vast majority of human diseases, and the healing effect is remarkable. However, the functional components and the corresponding pharmacological mechanism of the herbs are unclear. As one of the main means, the high-throughput sequencing (HTS) technologies have been employed to discover and parse the active ingredients of CHM. Moreover, a tremendous amount of effort is made to uncover the pharmacodynamic genes associated with the synthesis of active substances. Here, based on the genome-assembly and the downstream bioinformatics analysis, we present a comprehensive summary of the application of HTS on CHM for the synthesis pathways of active ingredients from two aspects: active ingredient properties and disease classification, which are important for pharmacological, herb molecular breeding, and synthetic biology studies.

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