Antidiabetic effect of sciadonic acid on type 2 diabetic mice through activating the PI3K-AKT signaling pathway and altering intestinal flora
文献类型： 外文期刊
作者： Chen, Lin 1 ; Jiang, Qihong 2 ; Lu, Hongling 1 ; Jiang, Chenkai 1 ; Hu, Wenjun 1 ; Yu, Shaofang 1 ; Xiang, Xingwei 2 ; Tan, Chin Ping 3 ; Feng, Yongcai 4 ; Zhang, Jianfang 4 ; Li, Mingqian 5 ; Shen, Guoxin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou, Zhejiang, Peoples R China
2.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou, Zhejiang, Peoples R China
3.Univ Putra Malaysia, Fac Food Sci & Technol, Dept Food Technol, Serdang, Malaysia
4.Xujing Hangzhou Biotechnol Res Inst Co Ltd, Hangzhou, Zhejiang, Peoples R China
5.Zhejiang Acad Tradit Chinese Med, Tongde Hosp Zhejiang Prov, Canc Inst Integrated Tradit Chinese & Western Med, Hangzhou, Zhejiang, Peoples R China
关键词： sciadonic acid; type 2 diabetes mellitus; insulin signaling pathway; gut microbiota; short-chain fatty acids
期刊名称：FRONTIERS IN NUTRITION （ 影响因子：5.0； 五年影响因子：5.7 ）
ISSN： 2296-861X
年卷期： 2022 年 9 卷
页码：
收录情况： SCI
摘要： Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by hyperglycemia. The aim of this work was to investigate the effect of sciadonic acid (SA) on disorders of glucolipid metabolism and intestinal flora imbalance and to further investigate its potential molecular mechanism of anti-diabetes. The experimental data indicated that SA could alleviate hyperlipidemia, insulin resistance, oxidative stress, the inflammatory response, repair liver function damage, and promote glycogen synthesis caused by T2DM. SA could also activate the PI3K/AKT/GLUT-2 signaling pathway, promote glucose metabolism gene expression, and maintain glucose homeostasis. Furthermore, 16S rRNA analysis revealed that SA could reduce the Firmicutes/Bacteroidota (F/B) ratio; promote norank_f__Muribaculaceae, Allobaculum, Akkermansia, and Eubacterium_siraeum_group proliferation; increase the levels of major short-chain fatty acids (SCFAs), such as acetic acid, propionic acid, and butyric acid; and maintain the homeostasis of the intestinal flora. In conclusion, these results suggested that SA could reshape the structural composition of intestinal microbes, activate the PI3K/AKT/GLUT2 pathway, improve insulin resistance, and decrease blood glucose levels.
- 相关文献
作者其他论文 更多>>
-
Genome Wide Identification, Expression Profiles and Regulatory Network Analysis of SOS Group of Genes in Camellia Sinensis
作者：Li, Wang;Lin, Chen;Shen, Guoxin;Bhattacharjee, Surjit;Mishra, Neelam
关键词：C. sinensis; SOS; Cis-acting elements; Expression pattern; Abiotic stress
-
Tea aroma retention strategies using tea polysaccharide conjugates: Insights from the yellowing process
作者：Xu, Anan;Tao, Meng;Tu, Zheng;Wang, Shanshan;Cao, Yanyan;Liu, Zhengquan;Chen, Lin
关键词：Tea aroma; Yellowing treatment; Tea polysaccharide conjugates; Interaction
-
MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori
作者：Ma, Chenkai;Xu, Fang;Hu, Chengjie;Yu, Wei;Xu, Xia;Ma, Chenkai;Xu, Fang;Hu, Chengjie;Cui, Chunguang;Du, Xin;Chen, Jine;Zhu, Linbao;Yu, Shaofang;He, Xingjian;Wang, Yongqiang;Xu, Xia
关键词：MPF; enzyme activity; embryo development; parthenogenesis;
Bombyx mori -
Genome-wide identification of PP2A gene family in Camellia sinensis reveals the potential role of CsPP2A-TON2/FASS1 in abiotic stress
作者：Bhattacharjee, Surjit;Mishra, Neelam;Miao, Ye;Lu, Honglin;Shen, Guoxin
关键词：Protein phosphatases; Genome-wide search; qRT-PCR; Stress-responsiveness; C. sinensis.; Drought stress; Salt stress; PP2A gene family
-
Decreased Cdk2 Activity Hindered Embryonic Development and Parthenogenesis Induction in Silkworm, Bombyx mori L.
作者：Hu, Chengjie;Jiang, Yonghou;Ma, Chenkai;Xu, Fang;Yu, Wei;Xu, Xia;Hu, Chengjie;Ma, Chenkai;Xu, Fang;Cui, Chunguang;Du, Xin;Chen, Jine;Zhu, Linbao;Yu, Shaofang;He, Xingjian;Wang, Yongqiang;Xu, Xia
关键词：Cdk2; AUZ454; oocytes; embryo; silkworm
-
PPARs Activity Affects the Hatchability Through Lipid Metabolism Regulation in Silkworm, Bombyx mori L.
作者：Xu, Xia;Cui, Chunguang;Song, Houhui;Wang, Yongqiang;Xu, Xia;Cui, Chunguang;Du, Xin;Chen, Jine;He, Xiuling;Zhu, Linbao;Hu, Chengjie;Xu, Fang;Ma, Chenkai;Yu, Shaofang;He, Xingjian;Wang, Yongqiang
关键词：PPARs activity; lipid metabolism; hatchability;
Bombyx mori L. -
Genome-wide identification reveals a bZIP transcription factor modulating chlorophyll catabolism during leaf yellowing in harvested Chinese flowering cabbage
作者：Zeng, Ze-xiang;Rong, Yuan;Chen, Lin;Wei, Wei;Shan, Wei;Kuang, Jian-fei;Lu, Wang-jin;Chen, Jian-ye;Fan, Zhong-qi;Su, Xin-guo;Han, Yan-chao;Chen, Hang-jun
关键词：WGCNA; Leaf senescence; Transcriptional regulation; 6-BA
