MPF Regulates Oocyte and Embryo Development During Parthenogenesis Induction in Silkworm, Bombyx mori
文献类型： 外文期刊
作者： Ma, Chenkai 1 ; Xu, Fang 1 ; Hu, Chengjie 1 ; Cui, Chunguang 2 ; Du, Xin 2 ; Chen, Jine 2 ; Zhu, Linbao 2 ; Yu, Shaofang 2 ; He, Xingjian 2 ; Yu, Wei 1 ; Wang, Yongqiang 2 ; Xu, Xia 1 ;
作者机构： 1.Zhejiang Sci Tech Univ, Coll Life Sci & Med, Hangzhou 310018, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China
关键词：
MPF; enzyme activity; embryo development; parthenogenesis;
期刊名称：INSECTS （ 影响因子：2.9； 五年影响因子：3.3 ）
ISSN：
年卷期： 2025 年 16 卷 4 期
页码：
收录情况： SCI
摘要： In most species, oocytes are arrested at the prophase or metaphase of meiosis I and require sperm-derived or external stimuli to resume meiosis. Maturation-promoting factor (MPF) is an oocyte maturation factor composing the catalytic subunit Cdc2 and the regulatory subunit CycB that can restart stalled meiosis. In this study, we demonstrated that MPF activity affected parthenogenesis induction in the model lepidopteran insect Bombyx mori using activator and inhibitor interference. We found that the upregulation of MPF activity significantly increased the parthenogenesis induction rate, whereas downregulation significantly reduced it. Furthermore, the inhibition of MPF activity also led to a delay in embryonic development. Given its evolutionary conservation, MPF emerges as a potential universal target for manipulating reproductive outcomes, offering broad applications in genetics and selective breeding.
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