文献类型： 外文期刊
作者： Chen, Haixia 1 ; He, Xiuling 2 ; Yang, Lei 2 ; Sun, Guangdong 2 ; Du, Xin 2 ; Xu, Xia 2 ; Hu, Fengyang 2 ; Zhao, Ayong 1 ; Wang, Yongqiang 1 ;
作者机构： 1.Zhejiang A&F Univ, Coll Anim Sci & Technol, Coll Vet Med, Hangzhou 311300, Peoples R China
2.Zhejiang Acad Agr Sci, Inst Sericulture & Tea, Hangzhou 310021, Peoples R China
关键词： Copper ions; Vascular endothelial growth factor; Silk hydrogel; Skin wounds; Wound healing; Biomaterials
期刊名称：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY （ 影响因子：4.9； 五年影响因子：5.2 ）
ISSN： 1773-2247
年卷期： 2025 年 113 卷
页码：
收录情况： SCI
摘要： Wound healing is a critical focus in the research of clinical treatments, wherein the application of biological materials has provided new directions for wound healing in recent years. Indeed, ideal wound dressings exhibiting antimicrobial, anti-inflammatory, and proangiogenic properties can effectively promote wound healing. In this study, gelatin-silk fibroin composite hydrogels incorporating Cu2+ and the vascular endothelial growth factor (VEGF) were reported as innovative biomaterials, demonstrating excellent biocompatibilities and wound healing effects. More specifically, Cu2+ was found to be pivotal in defining the antibacterial and antiinflammatory properties, ultimately accelerating the wound healing process. Additionally, the VEGF component promoted cell proliferation, migration, and neoangiogenesis. As a carrier with favorable mechanical properties and a good biocompatibility, the gelatin-silk fibroin hydrogel stabilized the release of Cu2+ and growth factors to provide sustained therapeutic effects. Subsequently, the developed gelatin-silk fibroin hydrogel loaded with Cu2+ and VEGF (CuSF@VEGF) was applied to promote wound healing. Ex vivo and in vivo experiments revealed that CuSF@VEGF effectively exerted antimicrobial and anti-inflammatory effects, promoted cell growth, enhanced neovascularization, and accelerated wound healing. Overall, this hydrogel exhibited a significant wound-repairing capability, offering a promising therapeutic strategy for trauma treatment.
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