Sciadonic acid ameliorates cyclophosphamide-induced immunosuppression by modulating the immune response and altering the gut microbiota
文献类型： 外文期刊
作者： Chen, Lin 1 ; Jiang, Qihong 1 ; Yao, Shiwei 2 ; Jiang, Chenkai 1 ; Lu, Hongling 1 ; Hu, Wenjun 1 ; Yu, Shaofang 1 ; Li, Mingqian 3 ; Feng, Yongcai 4 ; Tan, Chin Ping 4 ; Xiang, Xingwei 2 ; Shen, Guoxin 1 ;
作者机构： 1.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou 310021, Peoples R China
2.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China
3.Tongde Hosp Zhejiang Prov, Zhejiang Acad Tradit Chinese Med, Zhejiang Prov Key Lab Canc Prevent & Treatment Tec, Hangzhou, Peoples R China
4.Zhuji Lvkang Biotechnol Co Ltd, Shaoxing, Peoples R China
关键词： cyclophosphamide; gut microbiota; immunomodulatory activity; intestinal barrier; sciadonic acid
期刊名称：JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE （ 影响因子：4.1； 五年影响因子：4.2 ）
ISSN： 0022-5142
年卷期： 2024 年 104 卷 7 期
页码：
收录情况： SCI
摘要： BACKGROUNDCyclophosphamide (Cy) is a frequently used chemotherapeutic drug, but long-term Cy treatment can cause immunosuppression and intestinal mucosal damage. The intestinal mucosal barrier and gut flora play important roles in regulating host metabolism, maintaining physiological functions and protecting immune homeostasis. Dysbiosis of the intestinal flora affects the development of the intestinal microenvironment, as well as the development of various external systemic diseases and metabolic syndrome.RESULTSThe present study investigated the influence of sciadonic acid (SA) on Cy-induced immunosuppression in mice. The results showed that SA gavage significantly alleviated Cy-induced immune damage by improving the immune system organ index, immune response and oxidative stress. Moreover, SA restored intestinal morphology, improved villus integrity and activated the nuclear factor kappa B signaling pathway, stimulated cytokine production, and reduced serum lipopolysaccharide (LPS) levels. Furthermore, gut microbiota analysis indicated that SA increased t beneficial bacteria (Alistipes, Lachnospiraceae_NK4A136_group, Rikenella and Odoribacter) and decreased pathogenic bacteria (norank-f-Oscillospiraceae, Ruminococcus and Desulfovibrio) to maintain intestinal homeostasis.CONCLUSIONThe present study provided new insights into the SA regulation of intestinal flora to enhance immune responses. (c) 2024 Society of Chemical Industry.
- 相关文献
作者其他论文 更多>>
-
Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein
作者：Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Zhou, Yufang;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Yao, Shiwei;Chen, Hui;Xiang, Xingwei;Chen, Lin;Zhong, Yaqi;Cai, Yijing;Zhou, Yufang
关键词：Thunnus albacares eggs yolk glycoprotein; Lipid metabolism; Gut microbiota; Obesity; Hyperlipidemia
-
Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora
作者：Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Yang, Xingwen;Yao, Shiwei;Jiang, Qihong;Chen, Hui;Liu, Shulai;Xiang, Xingwei;Shen, Guoxin;Chen, Lin
关键词：AMPK signaling; high-fat diet; intestinal flora; lipid metabolism; non-alcoholic fatty liver; Tegillarca granosa polysaccharide
-
Creating Climate-Resilient Crops by Increasing Drought, Heat, and Salt Tolerance
作者：Sugumar, Tharanya;Smith, Jennifer;Zhang, Hong;Shen, Guoxin
关键词：abiotic stress; drought; food security; heat; salinity; climate change
-
Sciadonic acid attenuates high-fat diet-induced bone metabolism disorders in mice
作者：Yao, Shiwei;Xiang, Xingwei;Yao, Shiwei;Lu, Hongling;Jiang, Qihong;Jiang, Chenkai;Hu, Wenjun;Shen, Guoxin;Chen, Lin;Yao, Shiwei;Xiang, Xingwei;Zhou, Tianhuan;Du, Qun;Li, Mingqian;Tan, Chin Ping;Tan, Chin Ping;Feng, Yongcai
关键词：
-
Hypoglycemic mechanism of Tegillarca granosa polysaccharides on type 2 diabetic mice by altering gut microbiota and regulating the PI3K-akt signaling pathwaye
作者：Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Jiang, Qihong;Wang, Rui;Liu, Shulai;Xiang, Xingwei;Chen, Lin;Shen, Guoxin;Chen, Yin;Deng, Shanggui
关键词：Tegillarca granosa polysaccharide; Type 2 diabetes mellitus; Glycolipid metabolism; PI3K/Akt signaling pathway
-
Effects of Tea Seed Oil Extracted by Different Refining Temperatures on the Intestinal Microbiota of High-Fat-Diet-Induced Obese Mice
作者：Chen, Lin;Jiang, Qihong;Lu, Hongling;Jiang, Chenkai;Hu, Wenjun;Shen, Guoxin;Liu, Hanxiao;Xiang, Xingwei;Tan, Chin Ping;Zhou, Tianhuan
关键词：tea seed oil; oil refining process; high-fat diet; intestinal bacteria
-
Bioenzyme-nanoenzyme-chromogen all-in-one test strip for convenient and sensitive detection of malathion in water environment
作者：Zhang, Hanwen;Wang, Xini;Xiang, Xingwei;Jin, Jiabin;Han, Wei;Liu, Zhenjiang;Chen, Lin;Qin, Lei;Mao, Xiaoyan
关键词：Alkaline phosphatase; Malathion; Test strip; Rapid testing
