Improvement mechanism of lipid metabolism and gut microbiota in obese mice with Thunnus albacares eggs yolk glycoprotein
文献类型： 外文期刊
作者： Yao, Shiwei 1 ; Zhong, Yaqi 7 ; Cai, Yijing 7 ; Chen, Hui 1 ; Xiang, Xingwei 1 ; Zhou, Yufang 2 ; Chen, Lin 6 ;
作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China
2.Zhejiang Marine Dev Res Inst, Zhoushan 316000, Peoples R China
3.Key Lab Marine Fishery Resources Exploitment & Uti, Hangzhou 310014, Peoples R China
4.Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzhou, Hangzhou 310014, Peoples R China
5.Dalian Polytech Univ, Collaborat Innovat Ctr Seafood Deep Proc, Dalian 116034, Peoples R China
6.Zhejiang Acad Agr Sci, Inst Sericultural & Tea, Hangzhou 310021, Zhejiang, Peoples R China
7.Zhejiang Ocean Univ, Food & Pharm Coll, Zhoushan 316000, Peoples R China
关键词： Thunnus albacares eggs yolk glycoprotein; Lipid metabolism; Gut microbiota; Obesity; Hyperlipidemia
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2024 年 114 卷
页码：
收录情况： SCI
摘要： Thunnus albacares (T.albacares) is plentiful with a promising research value and application. However, research on lipid-reducing activity and gut microbiota of T.albacares eggs yolk glycoprotein (TGP) remains unreported. In this work, we investigated the potential mechanism of TGP intervention to improve the disorders of lipid metabolism, and regulate gut microbiota in mice induced by high-fat diet (HFD). The results demonstrated that TGP improved the dyslipidemia, liver inflammation, and restored the liver tissue structure caused by HFD. TGP prevented lipid overaccumulation by downregulating the relative mRNA expression of lipid synthesis genes. TGP also prevented differential expansion of microbiota, increased the abundance of beneficial bacteria Lactobacillus and Akkermansia, and decreased the abundance of harmful bacteria Desulfovibrio. Moreover, TGP promoted the production of short-chain fatty acids (SCFAs). All the above results provided some theoretical basis for the indepth development and application of TGP as a functional food for obesity and hyperlipidemia.
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