Exploring the Regulatory Effect of Tegillarca granosa Polysaccharide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Based on Intestinal Flora
文献类型： 外文期刊
作者： Yang, Xingwen 1 ; Yao, Shiwei 1 ; Jiang, Qihong 1 ; Chen, Hui 1 ; Liu, Shulai 1 ; Shen, Guoxin 4 ; Xiang, Xingwei 1 ; Chen, Lin 4 ;
作者机构： 1.Zhejiang Univ Technol, Coll Food Sci & Technol, Hangzhou 310014, Peoples R China
2.Key Lab Marine Fishery Resources Exploitment & Uti, Hangzhou 310014, Peoples R China
3.Natl R&D Branch Ctr Pelag Aquat Prod Proc Hangzhou, Hangzhou 310014, Peoples R China
4.Zhejiang Acad Agr Sci, Hangzhou 310021, Zhejiang, Peoples R China
关键词： AMPK signaling; high-fat diet; intestinal flora; lipid metabolism; non-alcoholic fatty liver; Tegillarca granosa polysaccharide
期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：4.5； 五年影响因子：5.6 ）
ISSN： 1613-4125
年卷期： 2024 年 68 卷 14 期
页码：
收录情况： SCI
摘要： To explore the potential mechanism of action of Tegillarca granosa polysaccharide (TGP) in treating nonalcoholic fatty liver disease (NAFLD), the study conducts in vivo experiments using male C57BL/6 mice fed a high-fat diet while administering TGP for 16 weeks. The study measures body weight, liver weight, serum biochemical markers, pathological histology, liver lipid accumulation, oxidative stress and inflammation-related factors, lipid synthesis and metabolism-related gene and protein expression, and the composition and abundance of intestinal flora. Additionally, short-chain fatty acid (SCFAs) content and the correlation between intestinal flora and environmental factors are measured. The results show that TGP effectively reduces excessive hepatic lipid accumulation, dyslipidemia, abnormal liver function, and steatosis in the mice with NAFLD. Moreover, TGP effectively regulates intestinal flora disorder, increases the diversity of intestinal flora, and affects the relative abundance of specific bacteria while also increasing the content of SCFAs. These findings provide a basis for exploring the regulatory effect of T. granosa polysaccharide on NAFLD based on intestinal flora and highlight its potential as a natural liver nutraceutical.
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