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Genome-wide and expression-profiling analyses of the cytochrome P450 genes in Tenebrionidea

文献类型： 外文期刊

作者： Wang, Yu-Qin 1 ; Li, Guang-Ya 1 ; Li, Lu 1 ; Song, Qi-Sheng 2 ; Stanley, David 3 ; Wei, Shu-Jun 1 ; Zhu, Jia-Ying 1 ;

作者机构： 1.Southwest Forestry Univ, Key Lab Forest Disaster Warning & Control Yunnan, Kunming, Yunnan, Peoples R China

2.Univ Missouri, Div Plant Sci & Technol, Columbia, MO USA

3.USDA ARS, Biol Control Insects Res Lab, Columbia, MO USA

4.Beijing Acad Agr & Forestry Sci, Inst Plant Protect, Beijing, Peoples R China

5.Southwest Forestry Univ, Key Lab Forest Resources Conservat & Utilizat Sou, Minist Educ, Kunming, Yunnan, Peoples R China

关键词： cytochrome P450 monooxygenase; expression profiling; genomics; molecular evolution; Tenebrio molitor

期刊名称：ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY （ 影响因子：2.454； 五年影响因子：2.11 ）

ISSN： 0739-4462

年卷期： 2022 年 111 卷 3 期

页码：

收录情况： SCI

摘要： Cytochrome P450 monooxygenases (CYPs) are present in almost all areas of the tree of life. As one of the largest and most diverse superfamilies of multifunctional enzymes, they play important roles in the metabolism of xenobiotics and biosynthesis of endogenous compounds, shaping the success of insects. In this study, the CYPome (an omics term for all the CYP genes in a genome) diversification was examined in the four Tenebrionidea species through genome-wide analysis. A total of 483 CYP genes were identified, of which 103, 157, 122, and 101 were respectively deciphered from the genomes of Tebebrio molitor, Asbolus verucosus, Hycleus cichorii and Hycleus phaleratus. These CYPs were classified into four major clans (mitochondrial, CYP2, CYP3, and CYP4), and clans CYP3 and CYP4 are most diverse. Phylogenetic analysis showed that most CYPs of these Tenebrionidea beetles from each clan had a very close 1:1 orthology to each other, suggesting that they originate closely and have evolutionally conserved function. Expression analysis at different developmental stages and in various tissues showed the life stage-, gut-, salivary gland-, fat body-, Malpighian tubule-, antennae-, ovary- and testis-specific expression patterns of T. molitor CYP genes, implying their various potential roles in development, detoxification, immune response, digestion, olfaction, and reproduction. Our studies provide a platform to understand the evolution of Tenebrionidea CYP gene superfamily, and a basis for further functional investigation of the T. molitor CYPs involved in various biological processes.

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