文献类型： 外文期刊
作者： Guo, Zhonglong 1 ; Kuang, Zheng 1 ; Zhao, Yongxin 1 ; Deng, Yang 1 ; He, Hao 1 ; Wan, Miaomiao 2 ; Tao, Yihan 2 ; Wang, Dong 4 ; Wei, Jianhua 1 ; Li, Lei 2 ; Yang, Xiaozeng 1 ;
作者机构： 1.Beijing Acad Agr & Forestry Sci, Beijing Agrobiotechnol Res Ctr, Beijing Key Lab Agr Genet Resources & Biotechnol, Beijing 100097, Peoples R China
2.Peking Univ, Peking Tsinghua Ctr Life Sci, Sch Life Sci, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China
3.Peking Univ, Sch Adv Agr Sci, Beijing 100871, Peoples R China
4.WeiRan Biotech, Beijing 100085, Peoples R China
期刊名称：NUCLEIC ACIDS RESEARCH （ 影响因子：19.16； 五年影响因子：17.21 ）
ISSN： 0305-1048
年卷期： 2022 年 50 卷 D1 期
页码：
收录情况： SCI
摘要： Nearly 200 plant genomes have been sequenced over the last two years, and new functions of plant microRNAs (miRNAs) have been revealed. Therefore, timely update of the plant miRNA databases by incorporating miRNAs from the newly sequenced species and functional information is required to provide useful resources for advancing plant miRNA research. Here we report the update of PmiREN2.0 (https://pmiren.com/) with an addition of 19 363 miRNA entries from 91 plants, doubling the amount of data in the original version. Meanwhile, abundant regulatory information centred on miRNAs was added, including predicted upstream transcription factors through binding motifs scanning and elaborate annotation of miRNA targets. As an example, a genome-wide regulatory network centred on miRNAs was constructed for Arabidopsis. Furthermore, phylogenetic trees of conserved miRNA families were built to expand the understanding of miRNA evolution across the plant lineages. These data are helpful to deduce the regulatory relationships concerning miRNA functions in diverse plants. Beside the new data, a suite of design tools was incorporated to facilitate experimental practice. Finally, a forum named 'PmiREN Community' was added for discussion and resource and new discovery sharing. With these upgrades, PmiREN2.0 should serve the community better and accelerate miRNA research in plants.
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