The Dynamics of Gene Expression Unraveling the Immune Response of Macrobrachium rosenbergii Infected by Aeromonas veronii
文献类型： 外文期刊
作者： Peng, Xin 1 ; Lan, Xuan 1 ; Zhong, Zhenxiao 1 ; Tu, Haihui 1 ; Yao, Xinyi 1 ; Tang, Qiongying 2 ; Xia, Zhenglong 3 ; Yang, Guoliang 1 ; Yi, Shaokui 1 ;
作者机构： 1.Huzhou Univ, Chinese Acad Fishery Sci, Key Lab Aquat Anim Genet Breeding & Nutr, Huzhou 313000, Peoples R China
2.Huzhou Univ, Zhejiang Prov Key Lab Aquat Resources Conservat &, Huzhou 313000, Peoples R China
3.Jiangsu Shufeng Prawn Breeding Co Ltd, Gaoyou 225654, Peoples R China
关键词： transcriptome; differentially expressed genes; Macrobrachium rosenbergii; Aeromonas veronii
期刊名称：GENES （ 影响因子：3.5； 五年影响因子：3.9 ）
ISSN：
年卷期： 2023 年 14 卷 7 期
页码：
收录情况： SCI
摘要： To further investigate the immune response of Macrobrachium rosenbergii against Aeromonas veronii, comparative transcriptomic analyses of the M. rosenbergii hepatopancreas were conducted on challenge and control groups at 6, 12, and 24 h post-infection (hpi), independently. A total of 51,707 high-quality unigenes were collected from the RNA-seq data, and 8060 differentially expressed genes (DEGs) were discovered through paired comparisons. Among the three comparison groups, a KEGG pathway enrichment analysis showed that 173 immune-related DEGs were considerably clustered into 28 immune-related pathways, including the lysosome, the phagosome, etc. Moreover, the expression levels of the four key immune-related genes (TOLL, PAK1, GSK3 & beta;, and IKK & alpha;) were evaluated at various stages following post-infection in the hepatopancreas, hemolymph, and gills. Both PAK1 and GSK3 & beta; genes were highly up-regulated in all three tissues at 6 hpi with A. veronii; TOLL was up-regulated in the hepatopancreas and hemolymph but down-regulated in the gill at 6 hpi, and IKK & alpha; was up-regulated in hemolymph and gill, but down-regulated in the hepatopancreas at 6 hpi. These findings lay the groundwork for understanding the immune mechanism of M. rosenbergii after contracting A. veronii.
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