Novel Angiotensin-Converting Enzyme Inhibitory Peptides Identified from Walnut Glutelin-1 Hydrolysates: Molecular Interaction, Stability, and Antihypertensive Effects
文献类型： 外文期刊
作者： Wang, Jing 1 ; Wang, Guoliang 1 ; Zhang, Yufeng 1 ; Zhang, Runguang 1 ; Zhang, Youlin 1 ;
作者机构： 1.Shaanxi Normal Univ, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China
2.Shaanxi Xueqian Normal Univ, Coll Life Sci & Food Engn, Xian 710100, Peoples R China
3.Minist Agr, Key Lab Se Enriched Prod Dev & Qual Control, Ankang 725000, Peoples R China
4.Chinese Acad Trop Agr Sci, Coconut Res Inst, Hainan Engn Ctr Coconut Further Proc, Wenchang 571339, Peoples R China
关键词： walnut glutelin-1; ACE inhibitory peptides; purification; molecular docking; antihypertensive effect
期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）
ISSN：
年卷期： 2022 年 14 卷 1 期
页码：
收录情况： SCI
摘要： In recent years, angiotensin-converting enzyme (ACE) inhibitory peptide has become a research hotspot because of its essential role in maintaining human blood pressure balance. In this study, two novel ACE inhibitory peptides of Val-Glu-Arg-Gly-Arg-Arg-lle-Thr-Ser-Val (Valine-Glutamate-Arginine-Glycine-Arginine-Arginine-Isoleucine-Threonine-Serine-Valine, VERGRRITSV) and Phe-Val-Ile-Glu-Pro-Asn-Ile-Thr-Pro-Ala (Phenylalanine-Valine-Isoleucine-Glutamate-Proline-Asparagine-Isoleucine-Threonine-Proline-Alanine, FVIEPNITPA) were isolated and purified from defatted walnut meal hydrolysates through a series of preparation processes including ultrafiltration, Sephadex G-15 gel chromatography, and reverse high performance liquid chromatography (RP-HPLC). Both peptides showed high ACE inhibitory activities. The molecular docking study revealed that VERGRRITSV and FVIEPNITPA were primarily attributed to the formation of strong hydrogen bonds with the active pockets of ACE. The binding free energies of VERGRRITSV and FVIEPNITPA with ACE were -14.99 and -14.69 kcal/mol, respectively. Moreover, these ACE inhibitory peptides showed good stability against gastrointestinal enzymes digestion and common food processing conditions (e.g., temperature and pH, sugar, and salt treatments). Furthermore, animal experiment results indicated that the administration of VERGRRITSV or FVIEPNITPA exhibited antihypertensive effects in spontaneously hypertensive rats. Our results demonstrated that walnut could be a potential source of bioactive peptides with ACE inhibitory activity.
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