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Dietary chitosan reversed the toxic effects of polystyrene microplastics on Nile tilapia (Oreochromis niloticus) liver by inhibiting mitochondrial damage

文献类型： 外文期刊

作者： Wu, Di 1 ; Lu, Xing 1 ; Dong, Li-Xue 1 ; Tian, Juan 1 ; Wen, Hua 1 ; Zhong, Shan 2 ; Li, Yun-feng 1 ; Jiang, Ming 1 ;

作者机构： 1.Chinese Acad Fishery Sci, Yangtze River Fisheries Res Inst, Key Lab Freshwater Biodivers Conservat, Minist Agr & Rural Affairs, Wuhan 430223, Peoples R China

2.Wuhan Univ, Sch Basic Med Sci, Wuhan 430071, Peoples R China

3.Hubei Prov Key Lab Allergy & Immunol, Wuhan 430071, Peoples R China

关键词： Polystyrene microplastics (PS-MPs); Liver damage; Mitochondrial damage; Chitosan

期刊名称：REVIEWS IN FISH BIOLOGY AND FISHERIES （ 影响因子：5.9； 五年影响因子：6.0 ）

ISSN： 0960-3166

年卷期： 2024 年 34 卷 3 期

页码：

收录情况： SCI

摘要： In recent years, the environmental pollution caused by microplastics (MPs) has attracted extensive attention. Numerous studies have shown that MPs could cause liver damage in aquatic animals. However, there is a limited range of technical approaches available to mitigate and minimize the detrimental impact of MPs on both wild fish populations and aquaculture operations. Thus, this study aimed to investigate the impact of dietary chitosan supplementation on the prevention and treatment of liver damage induced by exposure to polystyrene microplastics (PS-MPs) in Nile tilapia (Oreochromisniloticus). The results indicated that after two weeks of exposure, the liver of tilapia showed oxidative stress, inflammatory response and fibrosis. Meanwhile, after the chitosan addition, the oxidative stress, inflammatory response and fibrosis of tilapia liver were reversed, the pyroptosis and ferroptosis in tilapia liver were inhibited, the combination of mitochondria with PS-MPs in tilapia liver cells was inhibited, and the mitochondrial damage was reversed. In summary, the study confirmed the potential prophylaxis and treatment effect of dietary chitosan supplementation on PS-MPs exposure-induced liver damage in tilapia, and provided basic data for further studies on prophylaxis and treatment of the toxic effects of MPs. This study also presented efficacious strategies for alleviating the deleterious impacts of MPs on fish farming, thereby fostering sustainable and eco-friendly approaches in aquaculture.

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