Longan Polysaccharide as Adjuvant for Cyclophosphamide-Induced Side Effects in Murine Model
文献类型： 外文期刊
作者： Bai, Yajuan 1 ; Fan, Bei 1 ; Wang, Fengzhong 1 ; Zhang, Mingwei 4 ;
作者机构： 1.Chinese Acad Agr Sci CAAS, Inst Food Sci & Technol, Beijing 100193, Peoples R China
2.Chinese Acad Agr Sci, Natl Nanfan Res Inst Sanya, Sanya 572024, Peoples R China
3.Chinese Acad Agr Sci CAAS, Inst Western Agr, Changji 831100, Peoples R China
4.Guangdong Acad Agr Sci, Sericultural & Agrifood Res Inst, Guangzhou 510610, Peoples R China
关键词： longan polysaccharide; immunoregulation; antioxidant; cyclophosphamide; murine model; in vitro intestinal inflammation model
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2025 年 14 卷 16 期
页码：
收录情况： SCI
摘要： Identifying effective adjuvants to prevent and alleviate the adverse effects of chemotherapy remains a critical challenge in cancer therapy. This study investigated the protective effects of longan polysaccharide (LP) against cyclophosphamide-induced immunosuppression and oxidative stress in mice. Our findings revealed that LP administration significantly improved systemic immune function, as evidenced by marked increases in serum immunoglobulin levels (IgG2a: 1.82-fold, IgG2b: 1.46-fold, IgM: 1.26-fold, and IgG1: 1.22-fold) and key cytokines (IL-10: 1.53-fold, IL-12: 1.22-fold, and IFN-gamma: 1.20-fold), accompanied by substantial reductions in pro-inflammatory mediators (TGF-beta 1: 28.72% decrease and IL-21: 36.28% decrease). Concurrently, LP restored oxidative balance by increasing SOD, GSH, and NO levels in multiple organs (liver, kidneys, and small intestine) and serum. Mechanistic studies using an in vitro Caco-2/RAW264.7 coculture system revealed that four purified LP fractions (LPIa-LPIVa) effectively suppressed NF-kappa B pathway activation through downregulation of TLR4 expression, reduction of the p-I kappa B-alpha/I kappa B-alpha ratio, and inhibition of nuclear NF-kappa B translocation. These molecular effects correlated with decreased production of inflammatory mediators (TNF-alpha, IL-6, IL-8, iNOS, and NO). Collectively, these findings provide compelling evidence that LP possesses dual immunomodulatory and antioxidant capabilities, highlighting its potential as a natural adjuvant for alleviating chemotherapy-induced side effects.
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