A new fluorescent probe for hydrogen sulfide based on naphthalimide derivatives and its biological application
文献类型： 外文期刊
作者： Shi, Jiacheng 1 ; Zhang, Di 2 ; Li, Man 2 ; Wang, Yanliang 3 ; Liu, Lin 1 ; Wang, Tieliang 2 ; Guo, Fengqi 1 ; Wu, Xujin 2 ;
作者机构： 1.Zhengzhou Univ, Henan Inst Adv Technol, Zhengzhou 450003, Peoples R China
2.Henan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Henan Cereal Qual & Safety Testing Key Lab, Zhengzhou 450002, Peoples R China
3.Zhengzhou Univ Peoples Hosp, Henan Prov Peoples Hosp, Dept Nephrol, Henan Prov Key Lab Kidney Dis & Immunol, Zhengzhou 450003, Henan, Peoples R China
关键词： H2S; Fluorescence; Naphthalimide; Bioimaging
期刊名称：INORGANIC CHEMISTRY COMMUNICATIONS （ 影响因子：3.428； 五年影响因子：2.553 ）
ISSN： 1387-7003
年卷期： 2022 年 146 卷
页码：
收录情况： SCI
摘要： As a signal transduction molecule in organism, H2S plays an important role in many physiological processes. In this paper, a novel H2S fluorescent probe SBD was designed based on 1,8-naphthalimide and dini-trobenzenesulfonyl group. In DMSO-PBS solution, probe SBD could recognize H2S and change the color of so-lution from yellow to pink, realizing the naked eye recognition for H2S. In addition, probe SBD displayed high fluorescence enhancement rate (45-fold), good selectivity, strong anti-interference ability and the detection limit was as low as 152 nM. Most importantly, probe SBD showed very low cytotoxicity and had been successfully applied to image exogenous H2S in living cells.
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