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Meta-analysis of the effects of smooth endoplasmic reticulum aggregation on birth outcome

文献类型： 外文期刊

作者： Zhang, Hongqin 1 ; Hu, Wenhui 2 ; Zhong, Ying 2 ; Guo, Zhenhua 3 ;

作者机构： 1.Chengdu Jinjing Maternal & Child Hlth Hosp, Jinxin Res Inst Reprod Med & Genet, 3 Sanguantang Rd, Chengdu 610051, Peoples R China

2.Chengdu Xinan Gynecol Hosp, Jinxin Med Grp, 66 Bisheng Rd, Chengdu 610023, Peoples R China

3.Minist Agr & Rural Affairs, Heilongjiang Acad Agr Sci, Anim Husb Res Inst, Key Lab Combining Farming & Anim Husb, 368 Xuefu Rd, Harbin 150086, Peoples R China

关键词： Aggregation; Births; Oocyte; Smooth endoplasmic reticulum (SER)

期刊名称：BMC PREGNANCY AND CHILDBIRTH （ 影响因子：3.007； 五年影响因子：3.86 ）

ISSN：

年卷期： 2021 年 21 卷 1 期

页码：

收录情况： SCI

摘要： Background Smooth endoplasmic reticulum aggregation (SERa, SER+) has been reported to increase the risk of birth malformations and other abnormal outcomes, miscarriage, and perinatal complications. Other studies, however, suggest that SER+ embryos may develop into healthy infants. One report indicates that 25% of in vitro fertilization (IVF) centers discard SER+ oocytes. Thus, we investigated the effect of SER+ on birth outcomes in IVF and intracytoplasmic sperm injection. Methods We performed a literature search using PubMed, ScienceDirect, Cochrane, Embase, Ovid, and Scopus. We found a total of 1500 relevant studies between 1978 and 2020 and conducted a meta-analysis to study the effects of SER+ on live births, birth weight, and the number of metaphase II (MII) oocytes retrieved per cycle. Results Eleven eligible studies were included. If the SER+ zygote was evaluated again at the embryo transfer (ET) stage, SER+ did not affect birth or infant body weight. Stimulated ovaries producing too many oocytes per cycle were positively correlated with SER+ (OR = 1.28, 95% CI = 0.41-2.15; p = 0.004). SER+ was positively correlated with oocyte maturation rate, and observed heterogeneity in a previous meta-analysis was likely due to maternal age. Our data also showed that SER+ cycles produced more oocytes but achieved the same number of births from ET. Conclusions The use of SER+ MII oocytes is rare, with the collection of many oocytes in 1 cycle potentially inducing SER+. SER+ may be more common than we originally thought, as some SER+ is found in all oocytes. Although SER+ positively affected oocyte maturation rate, it did not affect births. We hypothesized that this is because the best embryos are chosen at every step of the process, and the oocytes with the poorest characteristics are removed. We therefore suggest a standard method for measuring SER+. Although embryos produced from SER+ cycles can be used, they should only be transferred when no other suitable embryos are available over several cycles.

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