文献类型： 外文期刊

作者： Cao, Yin-Hong ¹ ; Xu, Song-Song ¹ ; Shen, Min ³ ; Chen, Ze-Hui ¹ ; Gao, Lei ³ ; Lv, Feng-Hua ¹ ; Xie, Xing-Long ¹ ; Wang, ¹ ;

作者机构： 1.Chinese Acad Sci, Inst Zool, CAS Key Lab Anim Ecol & Conservat Biol, Beijing, Peoples R China

2.Univ Chinese Acad Sci UCAS, Coll Life Sci, Beijing, Peoples R China

3.Xinjiang Acad Agr & Reclamat Sci, Inst Anim Husb & Vet Med, Shihezi, Peoples R China

4.Xinjiang Acad Agr & Reclamat Sci, State Key Lab Sheep Genet Improvement & Hlth Bree, Shihezi, Peoples R China

5.China Agr Univ, Coll Anim Sci & Technol, Beijing, Peoples R China

6.Ningxia Acad Agr & Forestry Sci, Inst Anim Sci, Yinchuan, Ningxia, Peoples R China

7.TEAGASC, Anim & Grassland Res & Innovat Ctr, Moorepk, Fermoy, Cork, Ireland

8.Univ Cattolica Sacro Cuore, Dept Anim Sci Food & Nutr, Piacenza, Italy

9.Shahid Bahonar Univ Kerman, Fac Agr, Dept Anim Sci, Kerman, Iran

10.Payame Noor Univ, Dept Agr, Tehran, Iran

11.LK Ernst Fed Sci Ctr Anim Husb, Moscow, Podolsk, Russia

12.Univ Vet Med, Inst Anim Breeding & Genet, Vienna, Austria

13.State Vet Inst Jihlava, Dept Virol, Jihlava, Czech Republic

14.Univ Bari Aldo, Dipartimento Biosci Biotecnol & Biofarmaceut, 24 Moro, Bari, Italy

15.Justus Liebig Univ Giessen, Dept Anim Breeding & Genet, Giessen, Germany

16.Int Ctr Agr Res Dry Areas ICARDA, Small Ruminant Genom, Addis Ababa, Ethiopia

17.Univ Nottingham, Sch Life Sci, Univ Pk, Nottingham, England

18.Chinese Acad Agr Sci CAAS, Inst Anim Sci, CAAS ILRI Joint Lab Livestock & Forage Genet Reso, Beijing, Peoples R China

19.Int Livestock Res Inst ILRI, Livestock Genet Program, Nairobi, Kenya

20.Int Livestock Res Inst ILRI, Livestock Genet Program, Addis Ababa, Ethiopia

21.Univ Edinburgh, Ctr Trop Livestock Genet & Hlth CTLGH, Roslin Inst, Easter Bush, Midlothian, Scotland

22.Univ Alberta, Dept Biol Sci, Edmonton, AB, Canada

23.Govt Alberta, Fish & Wildlife Enforcement Branch Forens Unit, Edmonton, AB, Canada

24.Nat Resources Inst Finland Luke, Prod Syst, Jokioinen, Finland

25.Cardiff Univ, Sch Biosci, Cathays Pk, Cardiff, Wales

26.Cardiff Univ, Sustainable Pl Res Inst, Cardiff, Wales

27.Univ Utrecht, Fac Vet Med, Utrecht, Netherlands

28.Queensland Biosci Precinct, Commonwealth Sci & Ind Res Org Agr & Food, Brisbane, Qld, Australia

关键词： climate adaptation; genome-wide SNPs; whole-genome sequences; introgression; ovine; pneumonia

期刊名称：MOLECULAR BIOLOGY AND EVOLUTION （ 2020影响因子：16.24； 五年影响因子：18.67 ）

ISSN： 0737-4038

年卷期： 2021 年 38 卷 3 期

页码：

收录情况： SCI

摘要： How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining GOOK and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667-248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication.