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Powerful QTL mapping and favorable allele mining in an all-in-one population: a case study of heading date

文献类型： 外文期刊

作者： Wang, Pengfei 1 ; Yang, Ying 1 ; Li, Daoyang 1 ; Yu, Zhichao 1 ; Zhang, Bo 1 ; Zhou, Xiangchun 1 ; Xiong, Lizhong 1 ; Zhang, Jianwei 1 ; Wang, Lei 1 ; Xing, Yongzhong 1 ;

作者机构： 1.Huazhong Agr Univ, Natl Key Lab Crop Genet Improvement, Hubei Hongshan Lab, Wuhan 430070, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Crop Genet Resources, Haikou 571101, Peoples R China

3.Yazhouwan Natl Lab, Sanya 572024, Peoples R China

关键词： MAGIC population; population structure; bin map; novel casual variant; superior allele

期刊名称：NATIONAL SCIENCE REVIEW （ 影响因子：17.1； 五年影响因子：17.7 ）

ISSN： 2095-5138

年卷期： 2024 年 11 卷 8 期

页码：

收录情况： SCI

摘要： The multiparent advanced generation intercross (MAGIC) population is characterized with great potentials in power and resolution of quantitative trait locus (QTL) mapping, but single nucleotide polymorphism (SNP)-based GWAS does not fully reach its potential. In this study, a MAGIC population of 1021 lines was developed from four Xian and four Geng varieties from five subgroups of rice. A total of 44 000 genes showed functional polymorphisms among eight parents, including frameshift variations or premature stop codon variations, which provides the potential to map almost all genes of the MAGIC population. Principal component analysis results showed that the MAGIC population had a weak population structure. A high-density bin map of 24 414 bins was constructed. Segregation distortion occurred in the regions possessing the genes underlying genetic incompatibility and gamete development. SNP-based association analysis and bin-based linkage analysis identified 25 significant loci and 47 QTLs for heading date, including 14 known heading date genes. The mapping resolution of genes is dependent on genetic effects with offset distances of <55 kb for major effect genes and <123 kb for moderate effect genes. Four causal variants and noncoding structure variants were identified to be associated with heading date. Three to four types of alleles with strong, intermediate, weak, and no genetic effects were identified from eight parents, providing flexibility for the improvement of rice heading date. In most cases, japonica rice carries weak alleles, and indica rice carries strong alleles and nonfunctional alleles. These results confirm that the MAGIC population provides the exceptional opportunity to detect QTLs, and its use is encouraged for mapping genes and mining favorable alleles for breeding.

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