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MUSTN1 and FABP3 interact to regulate adipogenesis and lipid deposition

文献类型： 外文期刊

作者： Fu, Yu 1 ; Hao, Xin 1 ; Nie, Jingru 1 ; Zhang, Hongliang 1 ; Shang, Peng 4 ; Zhang, Bo 1 ; Zhang, Hao 1 ;

作者机构： 1.China Agr Univ, State Key Lab Anim Biotech Breeding, Beijing, Peoples R China

2.Chinese Acad Trop Agr Sci, Sanya Res Inst, Hainan, Peoples R China

3.Chinese Acad Trop Agr Sci, Coconut Res Inst, Hainan, Peoples R China

4.Xizang Agr & Anim Husb Coll, Coll Anim Sci, Linzhi, Peoples R China

关键词： MUSTN1; FABP3; adipogenesis; lipid deposition; PI3K/AKT

期刊名称：JOURNAL OF LIPID RESEARCH （ 影响因子：4.1； 五年影响因子：5.7 ）

ISSN： 0022-2275

年卷期： 2025 年 66 卷 5 期

页码：

收录情况： SCI

摘要： Lipid deposition is related to agricultural animal production and human health, and elucidating its molecular regulatory mechanisms is a topic of interest and a challenge in current scientific research. (MUSTN1) regulates growth and development, including muscle tissue; however, its role in fat deposition remains unknown. Thus, our objective was to determine this role. Our new findings were as follows: MUSTN1 was highly expressed in the fat tissue of pigs with strong adipose deposition capacity; functionally, MUSTN1 promoted the proliferation and adipogenic differentiation of porcine and mouse preadipocytes. MUSTN1 knockout mice were protected against HFD-induced obesity, hepatic steatosis, and insulin resistance; and fatty acid binding protein 3 was identified as an interacting protein of MUSTN1, which facilitated preadipocyte proliferation and differentiation by activating the phosphatidylinositol 3 kinase/AKT signaling pathways. This study reveals a positive regulator for fat development, which suggests a novel approach for studying obesity and animal genetic improvement through the modulation of MUSTN1 expression.

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