Three STATs are involved in the regulation of the expression of antimicrobial peptides in the triangle sail mussel, Hyriopsis cumingii
文献类型： 外文期刊
作者： Dai, Yun-Jia 1 ; Hui, Kai-Min 3 ; Zhang, Ying-Hao 2 ; Liu, Yan 2 ; Wang, Yu-Qing 2 ; Zhao, Li-Juan 2 ; Lin, Li 2 ; Chai, 1 ;
作者机构： 1.Henan Univ, State Key Lab Cotton Biol, Sch Life Sci, Kaifeng 475004, Peoples R China
2.Huazhong Agr Univ, Dept Aquat Anim Med, Coll Fisheries, Res Ctr Marine Biol, Wuhan 430070, Peoples R China
3.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Biodivers & Biotechnol, Nanjing 210046, Jiangsu, Peoples R China
4.Nanjing Normal Univ, Coll Life Sci, Jiangsu Key Lab Aquat Crustacean Dis, Nanjing 210046, Jiangsu, Peoples R China
5.Zhongkai Univ Agr & Engn, Guangzhou Key Lab Aquat Anim Dis & Waterfowl Bree, Coll Anim Sci & Technol, Guangzhou 510225, Guangdong, Peoples R China
6.Minist Agr, Key Lab Aquat Anim Immune Technol, Pearl River Fisheries Res Inst, Chinese Acad Fishery Sci,Key Lab Fishery Drug Dev, Guangzhou 510380, Guangdong, Peoples R China
关键词： Hyriopsis cumingii; Signal transducers and activators of transcription; Innate immunity; Antimicrobial peptides
期刊名称：FISH & SHELLFISH IMMUNOLOGY （ 影响因子：4.581； 五年影响因子：4.851 ）
ISSN： 1050-4648
年卷期： 2017 年 63 卷
页码：
收录情况： SCI
摘要： Janus kinase (Jak) and signal transducers and activators of transcription (STAT) signaling pathway is associated in antiviral and antibacterial immune response. Previous studies primarily investigated the function of STATs in mammals. For most invertebrates, only one STAT was found in each species, such as STAT92E was found in Drosophila melanogaster. The studies, which focus on the functional difference between various STATs in the same species of invertebrate, are limited. In the present study, three STATs (HcSTAT1, HcSTAT2 and HcSTAT3) were identified in triangle shell pearl mussel, Hyriopsis cumingii. Phylogenetic analysis showed that HcSTAT1 and HcSTAT3 were clustered with Homo sapiens STAT5, and HcSTAT2 was clustered with Pinctada fucata STAT and Crassostea gigas STAT6. All three STATs could be detected in all tested tissues (hemocytes, hepatopancreas, gill, mantle and foot), and were induced expression when challenged with Staphylococcus aureus or Aeromonas hydrophilia in hemocytes and hepatopancreas. HcSTAT1 regulated the expression of HcDef, HcWAP, HcThe and HcTNF. The expression of HcWAP and HcTNF was down-regulated in HcSTAT2-RNAi mussel. And HcSTAT3 affected the expression of HcTNF. The study is the first report of different functions in antibacterial immune responses between STATs in mollusks. (C) 2017 Elsevier Ltd. All rights reserved.
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