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Preparation and Properties of Carboxymethyl Chitosan/Alginate/Tranexamic Acid Composite Films

文献类型： 外文期刊

作者： Zhong, Qing-Kun 1 ; Wu, Ze-Yin 1 ; Qin, Ya-Qi 1 ; Hu, Zhang 1 ; Li, Si-Dong 1 ; Yang, Zi-Ming 2 ; Li, Pu-Wang 2 ;

作者机构： 1.Guangdong Ocean Univ, Sch Chem & Environm Sci, Zhanjiang 524088, Peoples R China

2.Chinese Acad Trop Agr Sci, Agr Prod Proc Res Inst, Zhanjiang 524001, Peoples R China

关键词： carboxymethyl chitosan; sodium alginate; tranexamic acid; composite films; hemostatic activity

期刊名称：MEMBRANES （ 影响因子：4.106； 五年影响因子：4.509 ）

ISSN：

年卷期： 2019 年 9 卷 1 期

页码：

收录情况： SCI

摘要： In this study, the porous composite films of carboxymethyl chitosan/alginate/tranexamic acid were fabricated, with calcium chloride as the crosslinking agent and glycerin as a plasticizer. The composite films were characterized by scanning electron microscopy (SEM) and Fourier transform infrared (FTIR) spectroscopy. The properties of the composite films, including water absorption, air permeability, and cumulative release rate, were tested. In addition, their hemostatic performance was evaluated. The results showed that the appearance of the films with good adhesion was smooth and porous. FTIR showed that chemical crosslinking between carboxymethyl chitosan and sodium alginate was successful. The excellent cumulative release of tranexamic acid in the composite films (60-80%) gives the films a significant procoagulant effect. This has good prospects for the development of medical hemostasis materials.

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