Pediococcus acidilactici AS185 attenuates early atherosclerosis development through inhibition of lipid regulation and inflammation in rats
文献类型： 外文期刊
作者： Wang, Chao 1 ; Wang, Han 1 ; Zhao, Zijian 2 ; Xiao, Shan 3 ; Zhao, Yujuan 2 ; Duan, Cuicui 2 ; Gao, Lei 2 ; Li, Shengyu 2 ;
作者机构： 1.Dalian Polytech Univ, Sch Biol Engn, 1 Qinggongyuan, Dalian 116034, Liaoning, Peoples R China
2.Jilin Acad Agr Sci, Inst Agrofood Technol, 1363 Sheng Tai St, Changchun 130033, Jilin, Peoples R China
3.Dongguan Univ Technol, Sch Chem Engn & Energy Technol, Engn Res Ctr Hlth Food Design & Nutr Regulat, Dongguan 523808, Peoples R China
关键词： Atherosclerosis; Pediococcus acidilactici; Probiotic; Lipid profile; Inflammation
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）
ISSN： 1756-4646
年卷期： 2019 年 60 卷
页码：
收录情况： SCI
摘要： Pathophysiologic mechanisms underlying atherosclerosis (AS) development are linked to dyslipidemia and inflammation. Pediococcus acidilactici AS185, a probiotic, was isolated from traditional farmers soybean paste (Yanji, China). This study aimed to assess P. acidilactici AS185 anti-atherosclerotic effects and elucidate molecular mechanisms of action using an early AS model of SD rats fed a high-fat diet with intraperitoneal vitamin D-3 (VD3) injections. For 8 weeks, model rats received P. acidilactici AS185 via gavage once/day. Post-treatment serum levels of inflammatory mediators, lipids, adhesion molecules, aortic histopathological characteristics and AS-related aortic protein expression levels were assessed. P. acidilactici AS185 administration markedly increased serum HDL-C and IL-10 levels, while reducing serum TG, LDL-C, TC, Ox-LDL, ICAM-1, VCAM-1, TNF-alpha, IFN- , IL-1 beta, and IL-6 levels. Notably, P. acidilactici AS185 inhibited p-p38 and ERK1/2 MAPK pathways and decreased Ox-LDL and CD36 expression to attenuate early AS by altering lipid profiles and MAPK-signaling-based inflammation.
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