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Methylglucosylation of Phenolic Compounds by Fungal Glycosyltransferase-Methyltransferase Functional Modules

文献类型： 外文期刊

作者： Xie, Linan 1 ; Zhang, Liwen 1 ; Bai, Jing 1 ; Yue, Qun 1 ; Zhang, Min 2 ; Li, Jiancheng 3 ; Wang, Chen 1 ; Xu, Yuquan 1 ;

作者机构： 1.Chinese Acad Agr Sci, Biotechnol Res Inst, 12 Zhongguancun South St, Beijing 100081, Peoples R China

2.Zhengzhou Univ, Sch Agr Sci, Kexue Ave 100, Zhengzhou 450001, Henan, Peoples R China

3.Hebei Acad Agr & Forestry Sci, Inst Plant Protect, 437 Dongguan St, Baoding 071000, Peoples R China

4.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, 7 Pengfei Rd, Shenzhen 518124, Peoples R China

关键词： glycosyltransferase; methylglycosylation; combinatorial biosynthesis; Hypocreales fungi; flavonoid

期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：5.279； 五年影响因子：5.269 ）

ISSN： 0021-8561

年卷期： 2019 年 67 卷 31 期

页码：

收录情况： SCI

摘要： Glycosylation endows both natural and synthetic small molecules with modulated physicochemical and biological properties. Plant and bacterial glycosyltransferases capable of decorating various privileged scaffolds have been extensively studied, but those from kingdom Fungi still remain underexploited. Here, we use a combination of genome mining and heterologous expression techniques to identify four novel glycosyltransferase-methyltransferase (GT-MT) functional modules from Hypocreales fungi. These GT-MT modules display decent substrate promiscuity and regiospecificity, methylglucosylating a panel of natural products such as flavonoids, stilbenoids, anthraquinones, and benzenediol lactones. Native GT-MT modules can be split up and regrouped into hybrid modules with similar or even improved efficacy as compared with native pairs. Methylglucosylation of kaempferol considerably improves its insecticidal activity against the larvae of oriental armyworm Mythimna separata (Walker). Our work provides a set of efficient biocatalysts for the combinatorial biosynthesis of small molecule glycosides that may have significant importance to the pharmaceutical, agricultural, and food industries.

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