Frondoplysins A and B, Unprecedented Terpene-Alkaloid Bioconjugates from Dysidea frondosa
文献类型： 外文期刊
作者： Jiao, Wei-Hua 1 ; Li, Jing 1 ; Zhang, Meng-Meng 3 ; Cui, Jie 1 ; Gui, Yu-Han 1 ; Zhang, Yun 4 ; Li, Jing-Ya 3 ; Liu, Ke-C 1 ;
作者机构： 1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, State Key Lab Oncogene & Related Genes,Res Ctr Ma, Shanghai 200127, Peoples R China
2.Shanghai Acad Agr Sci, Biotech Res Inst, Shanghai Key Lab Agr Genet & Breeding, Shanghai 201106, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, Shanghai 201203, Peoples R China
4.Qilu Univ Technol, Inst Biol, Jinan 250103, Shandong, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
ISSN： 1523-7060
年卷期： 2019 年 21 卷 16 期
页码：
收录情况： SCI
摘要： The chemical investigation of the marine sponge Dysidea frondosa discovered a pair of unprecedented bioconjugates that are composed of a meroterpene and an unusual psammaplysin alkaloid. The structures of frondoplysins A (1) and B (2) were characterized by analysis of HRMS and NMR data coupled with single-crystal X-ray diffraction. Frondoplysin A was found to be a potent inhibitor targeting protein-tyrosine phosphatase 1B (PTP1B) with an IC50 value of 0.39 mu M.
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