A comparatively study of menaquinone-7 isolated from Cheonggukjang with vitamin K-1 and menaquinone-4 on osteoblastic cells differentiation and mineralization
文献类型： 外文期刊
作者： Wu, Wei-Jie 1 ; Gao, Haiyan 1 ; Jin, Jong-Sik 3 ; Ahn, Byung-Yong 3 ;
作者机构： 1.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou 310021, Zhejiang, Peoples R China
2.Minist Agr, Key Lab Post Harvest Handling Fruits, Hangzhou, Zhejiang, Peoples R China
3.Chonbuk Natl Univ, Dept Oriental Med Resources, Coll Environm & Bioresource Sci, Iksan 570752, South Korea
关键词： Menaquinone; Proliferation; Osteoblasts; OPG/RANKL; Vitamin K
期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）
ISSN： 0278-6915
年卷期： 2019 年 131 卷
页码：
收录情况： SCI
摘要： The effect of menaquinone-7 isolated from cheonggukjang was comparatively investigated with vitamin K-1 and menaquinone-4 on cell differentiation and mineralization of the osteoblastic cell line MC3T3-E1. Results indicated that all vitamin K species significantly increased MC3T3-E1 cell proliferation, cellular alkaline phosphatase activity, osteocalcin synthesis, and calcium deposition in a dose-dependent manner. Menaquinone-4 and menaquinone-7 had more potent effects on calcium deposition than vitamin K-1, and their effects were only partly reduced by warfarin (gamma-carboxylation inhibitor) treatment, while warfarin abolished the induction activity of vitamin K-1 on calcification. This suggests that vitamin K-1 and K-2 (menaquinone-4 & menaquinone-7) may have different mechanisms in stimulating osteoblast mineralization. In addition, the mRNA expression ratio of osteoprotegerin and the receptor activator of nuclear factor-kB ligand was also dramatically increased by treatment with vitamin K-1 (62%), menaquinone-4 (247%), and menaquinone-7 (329%), suggesting that vitamin K may suppress the formation of osteoclast by up-regulating the ratio of osteoprotegerin/receptor activator of nuclear factor-kB ligand in osteoblasts. These results provide compelling evidence that vitamin K-1, menaquinone-4, and menaquinone-7 all can promote bone health, which might be associated with elevations in the osteoprotegerin/receptor activator of nuclear factor-kB ligand ratio.
- 相关文献
作者其他论文 更多>>
-
Dynamic changes in epidermal wax composition and quality of three goji berry varieties during postharvest storage
作者：Niu, Ben;Zong, Zihao;Ding, Yifan;Chen, Huizhi;Wu, Weijie;Ali, Maratab;Fang, Xiangjun;Shen, Chaoyi;Wang, Li-shu;Liu, Ruiling;Gao, Haiyan;Farag, Mohamed A.;Huang, Ting;Wang, Li-shu
关键词：Goji berry; Epidermal wax; Postharvest quality; Wax structure; Storage
-
VOZ-dependent priming of salicylic acid-dependent defense against Rhizopus stolonifer by β-aminobutyric acid requires the TCP protein TCP2 in peach fruit
作者：Wang, Kaituo;Li, Chunhong;Ji, Nana;Zou, Yanyu;Zheng, Yonghua;Wang, Kaituo;Li, Chunhong;Lei, Changyi;Zou, Yanyu;Tan, Meilin;Wang, Jinsong;Wang, Kaituo;Gao, Haiyan;Cao, Shifeng
关键词：beta-aminobutyric acid; vascular plant one-zinc finger; TEOSINTE-BRANCHED1/CYCLOIDEA/PCF; priming;
Rhizopus rot;Prunus persica -
Composition and micromorphological determination of blue honeysuckle fruit ( Lonicera caerulea L.) cuticular wax and its effects on fruit post-harvest quality
作者：Peng, Ze;Chen, Huizhi;Niu, Ben;Wu, Weijie;Chen, Hangjun;Ding, Yifan;Liu, Ruiling;Gao, Haiyan;Farag, Mohamed A.
关键词：Blue honeysuckle; Cuticular wax; GC-MS; SEM; Wax destruction; Postharvest quality
-
Silk protein: A novel antifungal and edible coating for strawberry preservation
作者：Wang, Yan;Wu, Weijie;Liu, Ruiling;Niu, Ben;Fang, Xiangjun;Chen, Hangjun;Wang, Guannan;Chen, Huizhi;Gao, Haiyan;Farag, Mohamed A.;Wang, Li-Shu;Yang, Hailong
关键词：Silk protease inhibitor; Silk fibroin; Degumming; Strawberry preservation; Active coating
-
Foxtail millet bran dietary fibres foster in vitro beneficial gut microbes and metabolites while suppressing pathobionts
作者：Li, Qi;Wang, Xiaowen;Ma, Chuanlong;Onyango, Stanley;Wu, Weijie;Gao, Haiyan;Li, Qiqiong
关键词：Soluble dietary fibre; Gut microbiota; In vitro fermentation; Metabolic function; Millet bran; Butyrate
-
Preparation and characterization of novel natural pigment-indicating film: Application in kiwifruit freshness monitoring
作者：Xia, Si;Fang, Xiangjun;Wu, Weijie;Wang, Guannan;Chen, Huizhi;Hu, Zhiwen;Liu, Ruilin;Gao, Haiyan;Wang, Li-Shu;Wang, Li-Shu
关键词：Natural pigment film; Highly variable color; Kiwifruit; Response surface; Freshness; CO 2 detection; Food quality indicators
-
Shiitake mushroom-derived extracellular nanovesicles: Preparation, characterization, and inhibition of Caco-2 cells
作者：Yang, Xueli;Zong, Zihao;Niu, Ben;Chen, Hangjun;Wu, Weijie;Fang, Xiangjun;Liu, Ruiling;Gao, Haiyan;Mu, Honglei
关键词：Shiitake mushroom; Extracellular nanovesicles; Sucrose gradient ultracentrifugation; Stability; Caco-2 cell
