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A comparatively study of menaquinone-7 isolated from Cheonggukjang with vitamin K-1 and menaquinone-4 on osteoblastic cells differentiation and mineralization

文献类型： 外文期刊

作者： Wu, Wei-Jie 1 ; Gao, Haiyan 1 ; Jin, Jong-Sik 3 ; Ahn, Byung-Yong 3 ;

作者机构： 1.Zhejiang Acad Agr Sci, Food Sci Inst, Hangzhou 310021, Zhejiang, Peoples R China

2.Minist Agr, Key Lab Post Harvest Handling Fruits, Hangzhou, Zhejiang, Peoples R China

3.Chonbuk Natl Univ, Dept Oriental Med Resources, Coll Environm & Bioresource Sci, Iksan 570752, South Korea

关键词： Menaquinone; Proliferation; Osteoblasts; OPG/RANKL; Vitamin K

期刊名称：FOOD AND CHEMICAL TOXICOLOGY （ 影响因子：6.023； 五年影响因子：5.844 ）

ISSN： 0278-6915

年卷期： 2019 年 131 卷

页码：

收录情况： SCI

摘要： The effect of menaquinone-7 isolated from cheonggukjang was comparatively investigated with vitamin K-1 and menaquinone-4 on cell differentiation and mineralization of the osteoblastic cell line MC3T3-E1. Results indicated that all vitamin K species significantly increased MC3T3-E1 cell proliferation, cellular alkaline phosphatase activity, osteocalcin synthesis, and calcium deposition in a dose-dependent manner. Menaquinone-4 and menaquinone-7 had more potent effects on calcium deposition than vitamin K-1, and their effects were only partly reduced by warfarin (gamma-carboxylation inhibitor) treatment, while warfarin abolished the induction activity of vitamin K-1 on calcification. This suggests that vitamin K-1 and K-2 (menaquinone-4 & menaquinone-7) may have different mechanisms in stimulating osteoblast mineralization. In addition, the mRNA expression ratio of osteoprotegerin and the receptor activator of nuclear factor-kB ligand was also dramatically increased by treatment with vitamin K-1 (62%), menaquinone-4 (247%), and menaquinone-7 (329%), suggesting that vitamin K may suppress the formation of osteoclast by up-regulating the ratio of osteoprotegerin/receptor activator of nuclear factor-kB ligand in osteoblasts. These results provide compelling evidence that vitamin K-1, menaquinone-4, and menaquinone-7 all can promote bone health, which might be associated with elevations in the osteoprotegerin/receptor activator of nuclear factor-kB ligand ratio.

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