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Citrus peel flavonoids improve lipid metabolism by inhibiting miR-33 and miR-122 expression in HepG2 cells

文献类型： 外文期刊

作者： Su, Dongxiao 1 ; Liu, Hesheng 2 ; Qi, Xiangyang 2 ; Dong, Lihong 4 ; Zhang, Ruifen 4 ; Zhang, Jie 2 ;

作者机构： 1.Guangzhou Univ, Sch Chem & Chem Engn, Guangzhou, Guangdong, Peoples R China

2.Zhejiang Wanli Univ, Zhejiang Prov Top Discipline Biol Engn Level A, Ningbo, Zhejiang, Peoples R China

3.Zhejiang Wanli Univ, Coll Biol & Environm Sci, Ningbo, Zhejiang, Peoples R China

4.Minist Agr, Key Lab Funct Foods, Sericultural & Agrifood Res Inst, Guangdong Acad Agr Sci, Guangzhou, Guangdong, Peoples R China

关键词： Citrus; flavonoid; lipid metabolism; miRNA; HepG2

期刊名称：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY （ 影响因子：2.043； 五年影响因子：2.017 ）

ISSN： 0916-8451

年卷期： 2019 年 83 卷 9 期

页码：

收录情况： SCI

摘要： Citrus plants are rich in flavonoids and beneficial for lipid metabolism. However, the mechanism has not been fully elucidated. Both citrus peel flavonoid extracts (CPFE) and a mixture of their primary flavonoid compounds, namely, nobiletin, tangeretin and hesperidin, citrus flavonoid purity mixture (CFPM), were found to have lipid-lowering effects on oleic acid-induced lipid accumulation in HepG2 cells. The carnitine palmitoyltransferase 1 alpha (CPT1 alpha) gene was markedly increased, while the fatty acid synthase (FAS) gene was significantly decreased by both CPFE and CFPM in oleic acid-treated HepG2 cells. Flavonoid compounds from citrus peel suppressed miR-122 and miR-33 expression, which were induced by oleic acid. Changes in miR-122 and miR-33 expression, which subsequently affect the expression of their target mRNAs FAS and CPT1 alpha, are most likely the principal mechanisms leading to decreased lipid accumulation in HepG2 cells. Citrus flavonoids likely regulate lipid metabolism by modulating the expression levels of miR-122 and miR-33.

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