文献类型： 外文期刊

作者： Guo, Lidong ¹ ; Wang, Liqun ³ ; Liu, Fei ² ; Li, Bailiang ² ; Tang, Yaru ² ; Yu, Shangfu ² ; Zhang, Danqing ² ; Huo, Guic ¹ ;

作者机构： 1.Heilongjiang Univ Chinese Med, Coll Pharm, Harbin 150040, Heilongjiang, Peoples R China

2.Northeast Agr Univ, Key Lab Dairy Sci, Minist Educ, 600 Changjiang Rd, Harbin 150030, Heilongjiang, Peoples R China

3.Heilongjiang Acad Agr Sci, Food Proc Inst, Harbin 150086, Heilongjiang, Peoples R China

关键词： Probiotics; Lactobacillus plantarum; Bile salt hydrolase; Cholesterol; Mechanism

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

ISSN： 1756-4646

年卷期： 2019 年 61 卷

页码：

收录情况： SCI

摘要： The present study aimed to evaluate bile salt hydrolase (BSH) activity and hypocholesterolemic effect of Lactobacillus plantarum KLDS 1.0344. BSH activity of the strain KLDS 1.0344 varied with different bile salts. High-cholesterol diet-induced male Sprague-Dawley rats were simultaneously administrated with strain KLDS 1.0344 for 4 weeks. The strain KLDS 1.0344 significantly improved lipid profiles in serum and liver, and increased fecal total cholesterol and total bile acids levels in high-cholesterol diet-fed rats (P < 0.05), and superior to L. rhamnosus GG. Moreover, expressions of genes related to cholesterol metabolism were regulated by the strain KLDS L0344, including down-regulation of hepatic HMGCR and FXR and intestinal NPC1L1, and up regulation of intestinal LXRa, ABCGS, ABCG8 and ABCA1 and hepatic CYP7A1 (P < 0.05). The hypocholeseterolemic effect of L. plantarum KLDS 1.0344 was modulated most likely by pathway of cholesterol absorption, synthesis, and catabolism, which might be partly due to its BSH activity.