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First demonstration of protective effects of purified mushroom polysaccharide-peptides against fatty liver injury and the mechanisms involved

文献类型： 外文期刊

作者： Zhao, Shuang 1 ; Zhang, Shuman 1 ; Zhang, Weiwei 3 ; Gao, Yi 5 ; Rong, Chengbo 1 ; Wang, Hexiang 6 ; Liu, Yu 1 ; Wong, Ja 1 ;

作者机构： 1.Beijing Acad Agr & Forestry Sci, Inst Plant & Environm Protect, Beijing 100097, Peoples R China

2.Minist Agr, Key Lab Vegetable Postharvest Proc, Beijing Key Lab Fruits & Vegetable Storage & Proc, Beijing 100097, Peoples R China

3.Chinese Acad Med Sci, Inst Med Plant Dev, Beijing 100193, Peoples R China

4.Peking Union Med Coll, Beijing 100193, Peoples R China

5.Beijing Xicheng Dist Hlth Care Ctr Mothers & Chil, Beijing 100053, Peoples R China

6.China Agr Univ, State Key Lab Agrobiotechnol, Beijing 100193, Peoples R China

7.China Agr Univ, Dept Microbiol, Beijing 100193, Peoples R China

8.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Shatin, Hong Kong, Peoples R China

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2019 年 9 卷

页码：

收录情况： SCI

摘要： Fatty liver (FLD) disease is a consequence of metabolic syndrome, which is a health problem worldwide with a phenomenal rise in prevalence. In this study, two hepatoprotective polysaccharide-peptides were extracted from the mushroom Auricularia polytricha followed by chromatographic fractionation of the extract on the ion exchanger DEAE-cellulose and gel filtration on Sephadex-200 to yield two purified fractions: APPI and APPII. The monosaccharide compositions, FT-IR, N-terminal sequences, internal peptide sequences and molecular weights of the two fractions were determined. Furthermore, their hepatoprotective effect on human hepatoma HepG2 cells in vitro and in an animal model of fatty liver disease was evidenced by the findings that APPI and APPII diminished lipid deposit in cells, blood and the liver, increased cellular antioxidant activity and viability, and protected the liver against injury. The mechanistic study revealed that APPI and APPII activated the adiponectin pathway, up-regulated expression of genes controlling free fatty acid (FFA) oxidation, such as AMPK, CPTl, ACOX1 and PPAR alpha genes, enhanced lipid metabolism, preserved hepatic function, promoted the antioxidant defense system and reduced lipid peroxidation. Hence the bioactive compounds of A. polytricha could serve as therapeutic agents in the food and pharmaceutical industries.

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