文献类型： 外文期刊
作者： Gao, Xiao-Qiang 1 ; Fei, Fan 1 ; Huo, Huan Huan 4 ; Huang, Bin 1 ; Meng, Xue Song 5 ; Zhang, Tao 5 ; Liu, Wei Bin 6 ; Liu 1 ;
作者机构： 1.Chinese Acad Fishery Sci, Yellow Sea Fisheries Res Inst, Qingdao Key Lab Marine Fish Breeding & Biotechnol, Minist Agr,Key Lab Sustainable Dev Marine Fisheri, Qingdao 266071, Shandong, Peoples R China
2.Qingdao Natl Lab Marine Sci & Technol, Lab Marine Fisheries Sci & Food Prod Proc, Qingdao 266071, Shandong, Peoples R China
3.Dalian Ocean Univ, Aquacultural Engn R&D Team, Dalian, Peoples R China
4.Jiangxi Agr Univ, Coll Anim Sci & Technol, Nanchang 330045, Jiangxi, Peoples R China
5.Dalian Tianzheng Ind Co Ltd, Dalian 116000, Peoples R China
6.Aquat Prod Bur Leting Cty, Tangshan, Peoples R China
关键词： Nitrite; Thyroid hormone; Iodothyronine deiodinase; Takifugu rubripes
期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.228； 五年影响因子：3.289 ）
ISSN： 1532-0456
年卷期： 2019 年 225 卷
页码：
收录情况： SCI
摘要： Nitrite (NO2-) can act as a toxic nitrogenous compound with the potential to disrupt endocrine systems in fish. The aim of the present study was to investigate the effects of nitrite on the thyroid endocrine system of Takifugu rubripes. Fish were exposed to 0, 0.5, 1, 3, and 6 mM nitrite concentrations. Blood was collected to assay the concentrations of thyroid-stimulating hormone (TSH), thyroxine (T-4), triiodothyronine (T-3), free thyroxine (FT4), free triiodothyronine (FT3), and 3,3,5'-triiodothyronine (rT(3)), as well as the activity of iodothyronine deiodinases (Dio1, Dio2, and Dio3,) after 0, 12, 24, 48, and 96 h of exposure to nitrite. The first branchial arch to the third branchial arch of T. rubripes were sampled and fixed, and thyroid morphology was observed. The results showed that exposure to nitrite significantly increased the concentrations of TSH, T-3, FT3, and reduced the concentrations of T-4, FT4, and rT(3). The activity of Dio1 and Dio2 increased significantly, whereas Dio3 activity decreased significantly. Additionally, thyroid follicles degenerated and became blurred and most colloid material disappeared 96 h after exposure to high nitrite concentrations. Based on these results, high nitrite concentration exposure can disturb thyroid hormone homeostasis, alter thyroid follicle morphology, and result in thyroid endocrine toxicity.
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