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Chronic thiamethoxam exposure impairs the HPG and HPT axes in adult Chinese rare minnow (Gobiocypris rarus): Docking study, hormone levels, histology, and transcriptional responses

文献类型： 外文期刊

作者： Zhu Lifei 1 ; Wei, Li 2 ; Zha, Jinmiao 3 ; Na, Li 5 ; Wang, Zijian 5 ;

作者机构： 1.Beijing Fisheries Res Inst, Beijing 100068, Peoples R China

2.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Key Lab Environm Biotechnol, POB 2871, Beijing 100085, Peoples R China

3.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Drinking Water Sci & Technol, Beijing 100085, Peoples R China

4.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, Beijing Key Lab Ind Wastewater Treatment & Reuse, Beijing 100085, Peoples R China

5.Chinese Acad Sci, Res Ctr Ecoenvironm Sci, State Key Lab Environm Aquat Chem, POB 2871, Beijing 100085, Peoples R China

关键词： Docking study; Plasma hormones; Thiamethoxam; Chinese rare minnow (Gobiocypris rants)

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.291； 五年影响因子：6.393 ）

ISSN： 0147-6513

年卷期： 2019 年 185 卷

页码：

收录情况： SCI

摘要： Thiamethoxam has emerged as an environmental contaminant detected in aqueous environments, and its endocrine-disrupting effect at chronic exposure in teleosts remains unknown. In the present study, a docking experiment and an in vivo test were integrated to systematically explore the toxic mechanisms of thiamethoxam in fish. Histological analysis, plasma VTG and hormone level (E2, 11-KT, T3 and T4) determinations, and HPG and HPT gene expression quantification were performed after Chinese rare minnow (Gobiocypris rants) was exposed to thiamethoxam (0, 0.5, 5, and 50 mu g/L) for 90 days. According to the docking study, thiamethoxam had different interactions with ER alpha, AR and TR alpha via hydrogen bonding. A decrease in body length and plasma T4 was observed in both genders. The histological damage in liver and delayed gonadal development were observed in both genders at 50 mu g/L thiamethoxam treatment. In males, the following HPG axis genes were upregulated: gnrh and cyp19b in the brain; vtg and cyp19a in the liver; and cyp17 and cyp19a in the gonad. In females, era in the liver was significantly upregulated with 0.5 mu g/L thiamethoxam treatment, and cyp17 in the gonad was upregulated with all treatment. The suppression of cyp19a, gnrh, cyp11a, and ttr was observed at the concentration of 5 mu g/L in the female liver. Taken together, the endocrine system of Chinese rare minnow might be disrupted after chronic exposure to thiamethoxam.

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