Effects of sodium butyrate on intestinal health and gut microbiota composition during intestinal inflammation progression in broilers
文献类型： 外文期刊
作者： Zou, X. 1 ; Ji, J. 1 ; Qu, H. 1 ; Wang, J. 1 ; Shu, D. M. 1 ; Wang, Y. 1 ; Liu, T. F. 1 ; Li, Y. 1 ; Luo, C. L. 1 ;
作者机构： 1.Guangdong Acad Agr Sci, State Key Lab Livestock & Poultry Breeding,Inst A, Guangdong Key Lab Anim Breeding & Nutr,Minist Agr, Guangdong Publ Lab Anim Breeding & Nutr,Key Lab P, Guangzhou 510640, Guangdong, Peoples R China
关键词： broiler; sodium butyrate; intestinal inflammation; microbiota composition
期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）
ISSN： 0032-5791
年卷期： 2019 年 98 卷 10 期
页码：
收录情况： SCI
摘要： Butyric acid is a beneficial feed additive used in animal production, including poultry production. However, there are few reports on butyric acid as a prophylactic treatment against intestinal inflammation in broilers. The current study explored the effect of sodium butyrate (SB) as a prophylactic treatment on the intestinal health and gut microbiota of broilers with intestinal inflammation induced by dextran sulfate sodium (DSS) by monitoring changes in intestinal histopathology, gut leakiness indicators, inflammatory cytokines, and gut microbiota composition. Sodium butyrate supplementation prior to DSS administration significantly reduced the lesion scores of intestinal bleeding (P < 0.05) and increased villus height and the total mucosa of the ileum (P < 0.05). Regardless of intestinal inflammation, supplementation with SB at 300 mg/kg significantly decreased the levels of D (-)-lactate (P < 0.05), interleukin-6, and interleukin-1 beta (P < 0.05) but increased the level of interleukin-10 (P < 0.05). The SB treatment did not affect the alpha diversity of intestinal microbiota during intestinal inflammation progression but altered their composition, and the microbial community structure of treated broilers was similar to that of control broilers. Taken together, our results reveal the importance of SB in improving intestinal development, inducing an anti-inflammatory effect during intestinal inflammation progression, and modulating the microbial community in broilers. Sodium butyrate seems to be optimized for anti-inflammatory effects at higher doses (300 mg/kg SB).
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