Chichen type III interferon produced by silkworm bioreactor induces ISG expression and restricts ALV-J infection in vitro
文献类型： 外文期刊
作者： Feng, Min 1 ; Zhang, Nan 1 ; Xie, Tingting 1 ; Ren, Feifei 1 ; Cao, Zhenming 1 ; Zeng, Xiaoqun 1 ; Swevers, Luc 2 ; Zhang 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China
2.Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Insect Mol Genet & Biotechnol, Athens 15341, Greece
关键词： Chicken IFN-lambda; ALV-J; Silkworm bioreactor; ISGs
期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）
ISSN： 0175-7598
年卷期： 2019 年 103 卷 20 期
页码：
收录情况： SCI
摘要： Type III interferon (IFN-lambda) has recently been shown to exert a significant antiviral impact against viruses in vertebrates. Avian leukosis virus subgroup J (ALV-J), which causes tumor disease and immunosuppression in infected chicken, is a retrovirus that is difficult to prevent and control because of a lack of vaccines and drugs. Here, we obtained chicken IFN-lambda (chIFN-lambda) using a silkworm bioreactor and demonstrated that chIFN-lambda has antiviral activity against ALV-J infection of both chicken embryo fibroblast cell line (DF1) and epithelial cell line (LMH). We found that chIFN-lambda triggered higher levels of particular type III interferon-stimulated genes (type III ISGs) including myxovirus resistance protein (Mx), viperin (RSAD2), and interferon-inducible transmembrane protein 3 (IFITM3) in DF1 and LMH cells. Furthermore, over-expression of Mx, viperin, and IFITM3 could inhibit ALV-J infection in DF1 and LMH cells. Therefore, these results suggested that the anti-ALV-J function of chIFN-lambda was specifically implemented by induction of expression of type III ISGs. Our data identified chIFN-lambda as a critical antiviral agent of ALV-J infection and provides a potentially and attractive platform for the production of commercial chIFN-lambda.
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