Chichen type III interferon produced by silkworm bioreactor induces ISG expression and restricts ALV-J infection in vitro
文献类型： 外文期刊
作者： Feng, Min 1 ; Zhang, Nan 1 ; Xie, Tingting 1 ; Ren, Feifei 1 ; Cao, Zhenming 1 ; Zeng, Xiaoqun 1 ; Swevers, Luc 2 ; Zhang 1 ;
作者机构： 1.South China Agr Univ, Coll Anim Sci, Guangdong Prov Key Lab Agroanim Genom & Mol Breed, 483 Wushan Rd, Guangzhou 510642, Guangdong, Peoples R China
2.Natl Ctr Sci Res Demokritos, Inst Biosci & Applicat, Insect Mol Genet & Biotechnol, Athens 15341, Greece
关键词： Chicken IFN-lambda; ALV-J; Silkworm bioreactor; ISGs
期刊名称：APPLIED MICROBIOLOGY AND BIOTECHNOLOGY （ 影响因子：4.813； 五年影响因子：4.697 ）
ISSN： 0175-7598
年卷期： 2019 年 103 卷 20 期
页码：
收录情况： SCI
摘要： Type III interferon (IFN-lambda) has recently been shown to exert a significant antiviral impact against viruses in vertebrates. Avian leukosis virus subgroup J (ALV-J), which causes tumor disease and immunosuppression in infected chicken, is a retrovirus that is difficult to prevent and control because of a lack of vaccines and drugs. Here, we obtained chicken IFN-lambda (chIFN-lambda) using a silkworm bioreactor and demonstrated that chIFN-lambda has antiviral activity against ALV-J infection of both chicken embryo fibroblast cell line (DF1) and epithelial cell line (LMH). We found that chIFN-lambda triggered higher levels of particular type III interferon-stimulated genes (type III ISGs) including myxovirus resistance protein (Mx), viperin (RSAD2), and interferon-inducible transmembrane protein 3 (IFITM3) in DF1 and LMH cells. Furthermore, over-expression of Mx, viperin, and IFITM3 could inhibit ALV-J infection in DF1 and LMH cells. Therefore, these results suggested that the anti-ALV-J function of chIFN-lambda was specifically implemented by induction of expression of type III ISGs. Our data identified chIFN-lambda as a critical antiviral agent of ALV-J infection and provides a potentially and attractive platform for the production of commercial chIFN-lambda.
- 相关文献
作者其他论文 更多>>
-
The transmembrane protein TMEM182 promotes fat deposition and alters metabolomics and lipidomics
作者：Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Luo, Wen;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua;Chen, Genghua;Lin, Zetong;Peng, Haoqi;Zhang, Shuai;Zhang, Zihao;Zhang, Xiquan;Nie, Qinghua
关键词：TMEM182; Fat formation; Metabolomics; Lipidomics
-
Foliar Application of Silica Nanoparticles Positively Influences the Early Growth Stage and Antioxidant Defense of Maize Under Low Light Stress
作者：Li, Guangyu;Ma, Ziwei;Zhang, Nan;Li, Meng;Mo, Zhaowen;Li, Guangyu;Ma, Ziwei;Li, Meng;Li, Wu;Li, Wu
关键词：Antioxidant response; Growth; Nitrogen metabolism; Photosynthetic pigments; Silica nanoparticles
-
PMAIP1 promotes J subgroup avian leukosis virus replication by regulating mitochondrial function
作者：Zhao, Yongxia;Zhao, Changbin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Zhao, Yongxia;Zhao, Changbin;Deng, Yuelin;Pan, Ming;Mo, Guodong;Liao, Zhiying;Zhang, Xiquan;Zhang, Dexiang;Li, Hongmei;Deng, Yuelin
关键词：ALV-J; PMAIP1; mitochondrial function; immune; DF-1
-
Live chicken body fat measurement technology based on bio-electrical impedance
作者：Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Zuo, Jiaming;Cheng, Shangshang;Li, Zhen;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Liang, Jinping;Li, Zhenhui;Nie, Qinghua;Zhang, Dexiang;Zhang, Xiquan;Li, Hongmei;Deng, Yuelin
关键词：BIA; Electrical impedance; Fat content; Broilers
-
Whole-transcriptome sequencing revealed the ceRNA regulatory network during the proliferation and differentiation of goose myoblast
作者：Zhang, Xiquan;Luo, Wen;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen;Xiao, Liangchao;Chen, Jiahui;He, Xueying;Zhang, Xiquan;Luo, Wen
关键词：Shitou goose; skeletal muscle; whole-transcriptome sequencing; lncRNA; ceRNA network
-
Experimental Warming Reduces the Grain Yield and Nitrogen Utilization Efficiency of Double-Cropping indica Rice in South China
作者：Yang, Taotao;Zou, Jixiang;Wu, Longmei;Bao, Xiaozhe;Zhang, Bin;Jiang, Yu;Zhang, Nan
关键词：climate warming; double-cropping indica rice; grain yield; nitrogen uptake; nitrogen utilization efficiency
-
LncEDCH1 g.1703613 T>C regulates chicken carcass traits by targeting miR-196-2-3p
作者：Yuan, Rongshuai;Cai, Bolin;Ma, Manting;Zhao, Changbin;Xian, Yuanrong;Nie, Qinghua;Zhang, Xiquan;Zhang, Dexiang;Zhang, Dexiang
关键词：LncEDCH1; miR-196-2-3p; single nucleotide polymorphism; carcass trait; chicken
