Sanggenon D from root bark of mulberry inhibits the growth of Staphylococcus aureus by moderating the fatty acid biosynthesis system
文献类型： 外文期刊
作者： Pang, Daorui 1 ; Wang, Weifei 1 ; Li, Erna 1 ; Shen, Weizhi 1 ; Mu, Lixia 1 ; Liao, Sentai 1 ; Liu, Fan 1 ;
作者机构： 1.Guangdong Acad Agr Sci, Key Lab Funct Foods, Guangdong Key Lab Agr Prod Proc, Minist Agr & Rural Affairs,Sericultural & Agrifoo, Guangzhou 510610, Guangdong, Peoples R China
关键词： Antibacterial activity; Sanggenon D; Mulberry root bark; Fatty acid biosynthesis enzyme system-associated genes; Fatty acid
期刊名称：INDUSTRIAL CROPS AND PRODUCTS （ 影响因子：5.645； 五年影响因子：5.749 ）
ISSN： 0926-6690
年卷期： 2019 年 140 卷
页码：
收录情况： SCI
摘要： Mulberry trees are an important crop widely cultivated in the Americas, Eurasia and Africa. Various prenylated flavonoids with different bioactivities have been identified in mulberry root bark. The objective of this study was to investigate antibacterial properties of several prenylated flavonoids from mulberry root bark and elucidate their mechanism(s) of action toward bacteria. Minimum inhibitory concentrations and time-dependent inhibiting curves of bacteria treated with mulberry root bark prenylated flavonoids were applied to identify bacteriostatic effects. Antibacterial effects were observed toward Staphylococcus aureus and Escherichia coif, the strongest effect was of sanggenon D toward Staphylococcus aureus. Scanning electron microscopy was used to observe structural changes of Staphylococcus aureus cells, gas chromatography-mass spectrometry was used to investigate the fatty acid components in cells, and assessment by quantitative real-time PCR was applied to elucidate changes in expression of fatty acid biosynthesis enzyme system-associated genes on sanggenon D treatment. The mechanism of the anti- Staphylococcus aureus activity of sanggenon D involves downregulation of expression of fatty acid biosynthesis enzyme-encoding genes, which may in turn affect biosynthesis of the Staphylococcus aureus cell membrane. Collectively, our results reveal that sanggenon D from mulberry root bark shows a potent antibacterial effect.
- 相关文献
作者其他论文 更多>>
-
Combining phospholipase A1 with monoacylglycerol lipase for crude vegetable oil degumming through improved oil-water separation
作者：Liu, Xuan;Huang, Chunjin;Lan, Dongming;Wang, Weifei;Wang, Yonghua;Wang, Weifei;Wang, Yonghua
关键词：Crude vegetable oil; Enzymatic degumming; Oil-water separation; Phospholipids; Glycerophosphoesters; Phospholipase A1; Monoacylglycerol lipase
-
Targeted and non-targeted metabolic characteristics of 6,7-dihydroxy-2,4-dimethoxyphenanthrene during simulated gastrointestinal digestion
作者：Li, Qian;Liu, Fan;Liao, Sentai;Zhou, Donglai;Xing, Dongxu;Zou, Yuxiao
关键词：Phenanthrenes; Chinese yam; Gastrointestinal digestion; Characteristic metabolism
-
Dietary supplementation of mulberry leaf oligosaccharides improves the growth, glucose and lipid metabolism, immunity, and virus resistance in largemouth bass (Micropterus salmoides)
作者：Zhou, Donglai;Zhong, Wenhao;Fu, Bing;Li, Erna;Li, Qingrong;Yang, Qiong;Zou, Yuxiao;Liao, Sentai;Xing, Dongxu;Zhou, Donglai;Li, Erna;Wang, Fubao;Zhong, Wenhao;Hao, Le;Liu, Zhenxing
关键词：largemouth bass; growth; serum biochemistry; liver metabolism; inflammation
-
Mulberry leaf extract reduces damage by regulating the oxidative response, immune response and intestinal flora of largemouth bass (Micropterus salmoides) under chronic heat stress
作者：Fu, Bing;Zhou, Donglai;Qiu, Xiaotong;Zheng, Jieqiu;Yang, Qiong;Xiao, Yang;Liao, Sentai;Li, Qingrong;Xing, Dongxu;Qiu, Xiaotong;Zheng, Jieqiu
关键词：mulberry leaf extract; largemouth bass; heat stress; intestinal flora; liver injury; immune ability
-
Antiviral activity of Morus alba L. . extract against pseudorabies virus
作者：Zhang, Xiaoai;Yang, Jian;Mo, Minying;Farooq, Muhammad;Li, Jianbo;Wei, Wenkang;Yao, Chunpeng;Yang, Jian;Liu, Fan
关键词：Antiviral activity; Morus alba; Ethanol extract; Pseudorabies virus
-
Volatile flavor and digestion behavior of peanut protein-based patties: Role of lipid type and oil phase incorporation method
作者：Chen, Ying;Zhang, Lin;Wang, Weifei
关键词：Plant-based patties; Acylglycerol; Volatile flavor; Digestion behavior
-
Inhibition Mechanism of Mulberry Prenylated Flavonoids Sanggenone D/Kuwanon G Against α-Glucosidase and the Regulation of Glucose via GLUT4 Pathway
作者：Wu, Erwen;Zhu, Yanqing;Zou, Yuxiao;Liu, Fan;Li, Qian;Wu, Erwen;Wei, Qingyi;Lu, Huijie;Li, Qian
关键词：alpha-glucosidase; inhibition mechanisms; molecular docking; Western blotting; structure-activity relationship
