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Pharmacokinetics of oxytetracycline in Pacific white shrimp, Penaeus vannamei, after oral administration of a single-dose and multiple-doses

文献类型： 外文期刊

作者： Ma, Rongrong 1 ; Wang, Yuan 2 ; Zou, Xiong 2 ; Fu, Guihong 2 ; Li, Chuanbu 2 ; Fan, Peili 2 ; Fang, Wenhong 2 ;

作者机构： 1.Ningbo Univ, Coll Marine Sci, Ningbo 315211, Zhejiang, Peoples R China

2.Chinese Acad Fishery Sci, East China Sea Fisheries Res Inst, Key Lab East China Sea Fishery Resources Exploita, Minist Agr, 300 Jungong Rd, Shanghai 200090, Peoples R China

关键词： Oxytetracycline; Pharmacokinetics; Single-dose and multiple-dose; Pacific white shrimp; Tissue distribution

期刊名称：AQUACULTURE （ 影响因子：4.242； 五年影响因子：4.723 ）

ISSN： 0044-8486

年卷期： 2019 年 512 卷

页码：

收录情况： SCI

摘要： The present study was designed to explore the pharmacokinetics and tissue levels of oxytetracycline in the Pacific white shrimp (Penaeus vannamei) after oral administration of a single-dose (100 mg/kg) and multiple doses (100 mg/kg, six times). Oxytetracycline concentrations in the hemolymph, hepatopancreas, and muscle of Pacific white shrimp were determined using high-performance liquid chromatography. Pharmacokinetic parameters were analyzed based on the statistical moment theory. The results showed faster absorption of oxytetracycline in hepatopancreas (T-max = 1 h) than in the hemolymph (T-max = 6 h) and muscles (T-max = 6 h) after single-dose oral administration. Meanwhile, the oxytetracycline peak concentration in the hepatopancreas was the highest (> 140 mu g/g), followed by the concentration in the hemolymph (> 25 mu g/mL), with the lowest concentration in the muscle (< 0.8 mu g/g) in the single-dose group. Tissue distribution (area under the curve (AUC)(0-infinity)) followed the order hepatopancreas > hemolymph > muscle, indicating that the hepatopancreas is the main organ involved in oxytetracycline metabolism in Pacific white shrimp. The t(1/2z) value of oxytetracycline in the hemolymph, hepatopancreas, and muscle were 11.01 h, 14.90 h and 23.53 h, respectively, indicating that oxytetracycline elimination in the muscle was the slowest among the tissues. In multiple-dose oral administration, some accumulation of oxytetracycline occurred in the hemolymph and muscle, while in the hepatopancreas, oxytetracycline reached a steady state following multiple-dose administration. The t(1/2z) values of oxytetracycline in the tissues were 20.52 h, 18.89 h, and 35.39 h, respectively, indicating that oxytetracycline elimination after multiple-dose administration in different tissues was slower than that after a single dose. In addition, the AUC(ss), C-trough, and C-av values of oxytetracycline were graded as hepatopancreas > hemolymph > muscle, showing that the hepatopancreas also plays an important role in drug metabolism and elimination after multiple-dose oral administration.

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