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Morphological Characterization and Gene Expression Patterns for Melanin Pigmentation in Rex Rabbit

文献类型： 外文期刊

作者： Hu, Shuaishuai 1 ; Zhai, Pin 2 ; Chen, Yang 1 ; Zhao, Bohao 1 ; Yang, Naisu 1 ; Wang, Manman 1 ; Xiao, Yeyi 1 ; Bao, Guol 1 ;

作者机构： 1.Yangzhou Univ, Coll Anim Sci & Technol, Yangzhou 225009, Jiangsu, Peoples R China

2.Jiangsu Acad Agr Sci, Anim Husb & Vet Res Inst, Nanjing 210014, Jiangsu, Peoples R China

3.Zhejiang Acad Agr Sci, Anim Husb & Vet Res Inst, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Rex rabbit; Skin; Melanin; Gene expression

期刊名称：BIOCHEMICAL GENETICS （ 影响因子：1.89； 五年影响因子：1.959 ）

ISSN： 0006-2928

年卷期： 2019 年 57 卷 5 期

页码：

收录情况： SCI

摘要： Animal melanin has an important role in the formation of animal fur and skin, which is determined by its quantities, character, and distribution. To identify the effect of melanin on the formation of multi-colored Rex rabbits (Black, Chinchilla, Beaver, Protein cyan, Protein yellow, White), the structure of hair follicles and melanin content in multi-colored Rex rabbit skins were observed by Hematoxylin and Eosin (H&E) staining and melanin staining, respectively. The melanin granules were primarily found in the epidermis and hair follicle roots. The melanin content of skin was measured by extracting melanin from skin tissue. The results demonstrated that the melanin content was the highest in the skin of black Rex rabbit. Additionally, we measured the mRNA and protein expression levels of melanin-related key genes (MITF and TYR) in the skin of different hair color by quantitative real-time PCR and Wes assay, respectively. The results revealed that the mRNA expression levels in the skin of black Rex rabbit was highly expressed when as compared with other Rex rabbit skin (P < 0.01), and they were the lowest in the skin of white Rex rabbit. Finally, correlation analysis was conducted between melanin content and the expression levels of mRNA and protein. The results indicated a significant correlation between melanin content and the mRNA expression of MITF (P < 0.05), but it was not correlated with the mRNA expression of TYR (P > 0.05). In summary, melanin deposition has important economic value, and the coat color of fur-bearing animals is partly determined by the melanin-related genes.

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