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Lethal toxicity and gene expression changes in embryonic zebrafish upon exposure to individual and mixture of malathion, chlorpyrifos and lambda-cyhalothrin

文献类型： 外文期刊

作者： Shen, Weifeng 1 ; Lou, Bao 1 ; Xu, Chao 2 ; Yang, Guiling 1 ; Yu, Ruixian 1 ; Wang, Xinquan 1 ; Li, Xinfang 1 ; Wang, Qia 1 ;

作者机构： 1.Zhejiang Acad Agr Sci, State Key Lab Qual & Safety Agroprod,Inst Hydrobi, Inst Qual & Stand Agroprod,Inst Hydrobiol,Minist, Key Lab Pesticide Residue Detect,Lab Hangzhou Ris, Hangzhou 310021, Zhejiang, Peoples R China

2.Zhejiang Univ Technol, Coll Environm, Hangzhou 310021, Zhejiang, Peoples R China

关键词： Mixture toxicity; Aquatic toxicity; Synergistic response; Gene expressions

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN： 0045-6535

年卷期： 2020 年 239 卷

页码：

收录情况： SCI

摘要： Pesticides are usually present as mixtures in water environments. Evaluating the toxic effects of individual pesticide may not be enough for protecting ecological environment due to interactions among substances. In this study, we aimed to examine the lethal doses and gene expression changes in zebrafish (Danio rerio) upon exposure to individual and mixture pesticides [malathion (MAL), chlorpyrifos (CHL) and lambda-cyhalothrin (LCY)]. Individual pesticide toxicity evaluation manifested that the toxicity of the three pesticides to D. rerio at various developmental stages (embryonic, larval, juvenile and adult stages) followed the order of LCY > CHL > MAL On the contrary, the least toxicity to the animals was discovered from MAL Most of the tested pesticides displayed lower toxicities to the embryonic stage compared with other life stages of zebrafish. Synergistic effects were monitored from two binary mixtures of LCY in combination with MAL or CHL and ternary mixture of MAL + CHL + LCY. The expressions of 16 genes involved in oxidative stress, immunity system, cell apoptosis and endocrine disruption at the mRNA level revealed that embryonic zebrafish were influenced by the individual or mixture pesticides. The expressions of Tnf, P53, TR alpha, Crh and Cyp19a exerted greater variations upon exposure to pesticide mixtures compared with their individual compounds. Collectively, the transcriptional responses of these genes might afford early warning biomarkers for identifying pollutant exposure, and the data acquired from this study provided valuable insights into the comprehensive toxicity of pesticide mixtures to zebrafish. (C) 2019 Elsevier Ltd. All rights reserved.

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