文献类型： 外文期刊

作者： Guo Jiaocen ¹ ; Ma Qingyun ² ; Kong Fangdong ² ; Xie Qingyi ² ; Zhou Liman ² ; Ding Qiong ¹ ; Wu Yougen ¹ ; Zhao Youxing ² ;

作者机构： 1.Hainan Univ, Coll Hort, Haikou 570228, Hainan, Peoples R China

2.Chinese Acad Trop Agr Sci, Inst Trop Biosci & Biotechnol, Hainan Key Lab Res & Dev Nat Prod Li Folk Med, Haikou 571101, Hainan, Peoples R China

关键词： Ganoderma ahmadii Steyaret; meroterpenoid compound; PTP1B inhibitory effect

期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：1.652； 五年影响因子：1.2 ）

ISSN： 0253-2786

年卷期： 2019 年 39 卷 11 期

页码：

收录情况： SCI

摘要： Three new meroterpenoids of ganoduriporols C similar to E were isolated from the fruiting bodies of Ganoderma ahmadii Steyaret by silica gel column, high performance liquid chromatography (HPLC) and other chromatography methods. Their structures were determined by spectroscopic techniques including NMR and HR-ESI-MS. Their inhibitory activities for protein tyrosine phosphatase 1B (PTP1B) in vitro were tested. The results showed that the three compounds had obvious PTP1B inhibitory activitiy with the IC50 values of 19.1, 17.81, and 29.6 mu mol.L-1, respectively.