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Chemical Constituents from the Cultures of Fungus Xylaria polymorpha

文献类型： 外文期刊

作者： Yang Ningning 1 ; Kong Fandong 2 ; Ma Qingyun 2 ; Huang Shengzhuo 2 ; Luo Duqiang; Zhou Liman 2 ; Dai Haofu 2 ; Yu Zhi 1 ;

作者机构： 1.Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Jiangsu, Peoples R China

2.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resources Trop Crops, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

3.Chinese Acad Trop Agr Sci, Key Lab Biol & Genet Resource

关键词： Xylaria polymorpha;sesquiterpene;AChE inhibitory activity;alpha-glucosidase inhibitory activity;anti-nematode activity

期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：1.652； 五年影响因子：1.2 ）

ISSN： 0253-2786

年卷期： 2017 年 37 卷 4 期

页码：

收录情况： SCI

摘要： Totally 21 compounds were isolated from the EtOAc extract of fermentation broth of fungus Xylaria polymorpha (Pers.: Fr.) Grer, including two new drimane-type sesquiterpenoids named polymorphines A and B (1 similar to 2) and one new phenyloxolane compound named 2-methyl-2-(4-hydroxymethylphenyl) oxolane (3), together with 18 known compounds 4 similar to 21. The structures of these compounds were elucidated by NMR and single-crystal X-ray diffraction analysis. Compound 2 exhibited anti-acetylcholinesterase and alpha-glucosidase inhibitory activities. Moreover, compound 3 showed moderate inhibitory activitiy against the nematode Panagrellus redivivus with mortality ratio of 59.6% at 2.5 mg/mL.

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