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Structure Elucidation of Flavonoids from Antiaris toxicaria Roots

文献类型： 外文期刊

作者： Que Dongmei 1 ; Mei Wenli 1 ; Wu Jiao 1 ; Han Zhuang 1 ; Dai Haofu 1 ;

作者机构： 1.Chinese Acad Trop Agr Sci, Key Lab Trop Crop Biotechnol, Minist Agr, Inst Trop Biosci & Biotechnol, Haikou 571101, Peoples R China

关键词： Antiaris toxicaria;prenylflavanone;antiarone K;antibacterial activity;cytotoxicity

期刊名称：CHINESE JOURNAL OF ORGANIC CHEMISTRY （ 影响因子：1.652； 五年影响因子：1.2 ）

ISSN： 0253-2786

年卷期： 2009 年 29 卷 9 期

页码：

收录情况： SCI

摘要： A new prenylflavanone, antiarone K (1), together with seven known flavonoids, antiarones B, F similar to I(2 similar to 6), (+/-)-sigmoidin A (7), and 2-[2,3-dihydro-4-hydroxy-2-(2-hydroxy-2-propyl)-5-methoxy-1H-inden- 1-yl]-1-(2,4,6-trihydroxyphenyl)ethanone (8), was isolated from the ethanolic extract of the roots of Antiaris toxicaria (Pers.) Lesch collected from Hainan. The structures were established by spectroscopic methods (IR, 1D-, 2D-NMR, and HR-ESIMS). Compounds 1 and 3 possessed inhibitory effects on Staphylococcus aureus, and compound 3 possessed inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) as shown by the filter paper disc diffusion method. Compounds 1, 6 similar to 8 showed inhibitory activity towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines by MTT assay.

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